Gene description for Apln
Gene name	apelin
Gene symbol	Apln
Other names/aliases	6030430G11Rik Apel
Species	Mus musculus
Database cross references - Apln
ExoCarta	ExoCarta_30878
Vesiclepedia	VP_30878
Entrez Gene	30878
UniProt	Q9R0R4
Apln identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Apln

Molecular Function     signaling receptor binding GO:0005102 ISO     hormone activity GO:0005179 ISO     hormone activity GO:0005179 ISS     apelin receptor binding GO:0031704 ISO     apelin receptor binding GO:0031704 ISS     identical protein binding GO:0042802 ISO Biological Process     angiogenesis GO:0001525 IEA     regulation of the force of heart contraction GO:0002026 ISO     negative regulation of systemic arterial blood pressure GO:0003085 ISO     G protein-coupled receptor signaling pathway GO:0007186 ISO     gastrulation GO:0007369 IEA     feeding behavior GO:0007631 ISO     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of heart rate GO:0010460 ISO     negative regulation of gene expression GO:0010629 IEA     negative regulation of gene expression GO:0010629 ISO     positive regulation of heat generation GO:0031652 ISO     negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IEA     negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 ISO     positive regulation of phosphorylation GO:0042327 ISO     drinking behavior GO:0042756 ISO     drinking behavior GO:0042756 ISS     negative regulation of blood pressure GO:0045776 ISO     negative regulation of blood pressure GO:0045776 ISS     positive regulation of heart contraction GO:0045823 ISO     positive regulation of heart contraction GO:0045823 ISS     negative regulation of vasoconstriction GO:0045906 ISO     regulation of body fluid levels GO:0050878 ISO     positive regulation of corticotropin secretion GO:0051461 ISO     positive regulation of corticotropin-releasing hormone secretion GO:0051466 ISO     apelin receptor signaling pathway GO:0060183 IDA     apelin receptor signaling pathway GO:0060183 ISO     apelin receptor signaling pathway GO:0060183 ISS     coronary vasculature development GO:0060976 IMP     positive regulation of miRNA transcription GO:1902895 IEA     positive regulation of miRNA transcription GO:1902895 ISO     positive regulation of G protein-coupled receptor internalization GO:1904022 IDA     positive regulation of G protein-coupled receptor internalization GO:1904022 ISO     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IEA     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO     positive regulation of vascular endothelial cell proliferation GO:1905564 IEA     positive regulation of vascular endothelial cell proliferation GO:1905564 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular region GO:0005576 ISS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 ISO     perinuclear region of cytoplasm GO:0048471 ISO