Gene description for Apln
Gene name apelin
Gene symbol Apln
Other names/aliases 6030430G11Rik
Apel
Species Mus musculus
 Database cross references - Apln
ExoCarta ExoCarta_30878
Entrez Gene 30878
UniProt Q9R0R4  
 Apln identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Apln
Molecular Function
    G-protein coupled receptor binding GO:0001664 IBA
    apelin receptor binding GO:0031704 ISO
    receptor binding GO:0005102 ISA
    hormone activity GO:0005179 IEA
Biological Process
    signal transduction GO:0007165 IEA
    positive regulation of heat generation GO:0031652 ISO
    regulation of the force of heart contraction GO:0002026 ISO
    positive regulation of phosphorylation GO:0042327 ISO
    feeding behavior GO:0007631 ISO
    drinking behavior GO:0042756 ISO
    negative regulation of vasoconstriction GO:0045906 ISO
    positive regulation of vasodilation GO:0045909 ISO
    regulation of body fluid levels GO:0050878 ISO
    G-protein coupled receptor signaling pathway GO:0007186 ISA
    positive regulation of cell proliferation GO:0008284 ISO
    negative regulation of blood pressure GO:0045776 ISO
    positive regulation of corticotropin secretion GO:0051461 ISO
    positive regulation of corticotropin-releasing hormone secretion GO:0051466 ISO
    regulation of respiratory gaseous exchange GO:0043576 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Apln in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Apln
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Apln is involved
No pathways found





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