Gene description for Ap3b1
Gene name adaptor-related protein complex 3, beta 1 subunit
Gene symbol Ap3b1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ap3b1
ExoCarta ExoCarta_309969
Entrez Gene 309969
 Ap3b1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ap3b1
Molecular Function
    molecular_function GO:0003674 ND
    protein phosphatase binding GO:0019903 ISO
    GTP-dependent protein binding GO:0030742 ISO
Biological Process
    positive regulation of NK T cell differentiation GO:0051138 ISO
    melanosome organization GO:0032438 ISO
    anterograde synaptic vesicle transport GO:0048490 ISO
    protein targeting to lysosome GO:0006622 ISO
    anterograde axon cargo transport GO:0008089 ISO
    antigen processing and presentation GO:0019882 ISO
    biological_process GO:0008150 ND
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 ISO
    blood coagulation GO:0007596 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    cellular_component GO:0005575 ND
    AP-3 adaptor complex GO:0030123 IEA
    cell GO:0005623 ISO
    intracellular GO:0005622 ISO
    lysosomal membrane GO:0005765 ISO
 Experiment description of studies that identified Ap3b1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ap3b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ap3b1 is involved
No pathways found





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