Gene description for Sema5a
Gene name	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Gene symbol	Sema5a
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Sema5a
ExoCarta	ExoCarta_310207
Vesiclepedia	VP_310207
Entrez Gene	310207
UniProt	D3ZTD8
Sema5a identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Sema5a

Molecular Function     axon guidance receptor activity GO:0008046 ISO     semaphorin receptor binding GO:0030215 IBA     semaphorin receptor binding GO:0030215 IEA     semaphorin receptor binding GO:0030215 ISO     semaphorin receptor binding GO:0030215 ISS     chondroitin sulfate proteoglycan binding GO:0035373 IMP     heparan sulfate proteoglycan binding GO:0043395 IMP     chemorepellent activity GO:0045499 IBA     syndecan binding GO:0045545 IPI Biological Process     branching involved in blood vessel morphogenesis GO:0001569 ISO     neural crest cell migration GO:0001755 IBA     positive regulation of endothelial cell proliferation GO:0001938 ISO     positive regulation of endothelial cell proliferation GO:0001938 ISS     blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 ISO     blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 ISS     negative regulation of cell adhesion GO:0007162 ISO     negative regulation of cell adhesion GO:0007162 ISS     nervous system development GO:0007399 IEA     axon guidance GO:0007411 IBA     axon guidance GO:0007411 ISO     axonal fasciculation GO:0007413 IDA     diencephalon development GO:0021536 IMP     cell differentiation GO:0030154 IEA     positive regulation of cell migration GO:0030335 IBA     positive regulation of actin filament depolymerization GO:0030836 ISO     positive regulation of actin filament depolymerization GO:0030836 ISS     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISS     axon extension GO:0048675 IBA     axon extension GO:0048675 ISO     branching morphogenesis of an epithelial tube GO:0048754 ISO     positive regulation of axon extension involved in axon guidance GO:0048842 IMP     negative regulation of axon extension involved in axon guidance GO:0048843 IMP     detection of light stimulus involved in visual perception GO:0050908 ISO     positive chemotaxis GO:0050918 ISO     positive chemotaxis GO:0050918 ISS     negative chemotaxis GO:0050919 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     cell chemotaxis GO:0060326 ISO     cell chemotaxis GO:0060326 ISS     semaphorin-plexin signaling pathway GO:0071526 IBA     semaphorin-plexin signaling pathway GO:0071526 ISO     semaphorin-plexin signaling pathway GO:0071526 ISS     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     positive regulation of canonical Wnt signaling pathway GO:0090263 ISS     neuron projection guidance GO:0097485 ISO     regulation of plasma membrane bounded cell projection organization GO:0120035 IEA     neuron projection extension GO:1990138 ISO     signal clustering GO:1990256 IMP     signal clustering GO:1990256 ISO     signal clustering GO:1990256 ISS     negative regulation of endothelial cell apoptotic process GO:2000352 ISO     negative regulation of endothelial cell apoptotic process GO:2000352 ISS     positive regulation of endothelial cell chemotaxis GO:2001028 ISO     positive regulation of endothelial cell chemotaxis GO:2001028 ISS Subcellular Localization     plasma membrane GO:0005886 IBA     membrane GO:0016020 IDA     membrane GO:0016020 IEA     membrane GO:0016020 ISO