Gene description for Vinc
Gene name Vinculin
Gene symbol Vinc
Other names/aliases CG3299
CT11081
DmelCG3299
Dmvincp
EG:103B4.1
Vin
Vin2EF
vinc
Species Drosophila melanogaster
 Database cross references - Vinc
ExoCarta ExoCarta_31201
Entrez Gene 31201
UniProt O46037  
 Vinc identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Vinc
Molecular Function
    structural molecule activity GO:0005198 IEA
    actin binding GO:0003779 ISS
    actin filament binding GO:0051015 IEA
Biological Process
    cell-matrix adhesion GO:0007160 IEA
    cell adhesion GO:0007155 NAS
    neuron projection morphogenesis GO:0048812 IMP
    cytoskeletal anchoring at plasma membrane GO:0007016 ISS
    phagocytosis GO:0006909 IMP
Subcellular Localization
    actin cytoskeleton GO:0015629 IEA
    focal adhesion GO:0005925 ISS
 Experiment description of studies that identified Vinc in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vinc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vinc is involved
PathwayEvidenceSource
Platelet degranulation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here