Gene description for Pon3
Gene name paraoxonase 3
Gene symbol Pon3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pon3
ExoCarta ExoCarta_312086
Vesiclepedia VP_312086
Entrez Gene 312086
UniProt Q68FP2  
 Pon3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pon3
Molecular Function
    aryldialkylphosphatase activity GO:0004063 IEA
    arylesterase activity GO:0004064 IBA
    arylesterase activity GO:0004064 IDA
    arylesterase activity GO:0004064 IEA
    arylesterase activity GO:0004064 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    metal ion binding GO:0046872 IEA
    dihydrocoumarin hydrolase activity GO:0047856 IDA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 IEA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 ISO
Biological Process
    renal sodium ion transport GO:0003096 IEA
    renal sodium ion transport GO:0003096 ISO
    response to toxic substance GO:0009636 IBA
    phenylacetate catabolic process GO:0010124 IDA
    negative regulation of superoxide anion generation GO:0032929 IEA
    negative regulation of superoxide anion generation GO:0032929 ISO
    coumarin catabolic process GO:0046226 IDA
    carboxylic acid catabolic process GO:0046395 IEA
    carboxylic acid catabolic process GO:0046395 ISO
    establishment of localization in cell GO:0051649 IEA
    establishment of localization in cell GO:0051649 ISO
    lactone catabolic process GO:1901335 IEA
    lactone catabolic process GO:1901335 ISO
    regulation of cellular response to drug GO:2001038 IEA
    regulation of cellular response to drug GO:2001038 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Pon3 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pon3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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