Gene description for Pon3
Gene name paraoxonase 3
Gene symbol Pon3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pon3
ExoCarta ExoCarta_312086
Entrez Gene 312086
UniProt Q68FP2  
 Pon3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pon3
Molecular Function
    3,4-dihydrocoumarin hydrolase activity GO:0018733 IDA
    metal ion binding GO:0046872 IEA
    arylesterase activity GO:0004064 ISO
    dihydrocoumarin hydrolase activity GO:0047856 IDA
    protein homodimerization activity GO:0042803 ISO
    aryldialkylphosphatase activity GO:0004063 IEA
Biological Process
    dephosphorylation GO:0016311 IEA
    carboxylic acid catabolic process GO:0046395 ISO
    phenylacetate catabolic process GO:0010124 IDA
    aromatic compound catabolic process GO:0019439 ISO
    coumarin catabolic process GO:0046226 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular space GO:0005615 IMP
 Experiment description of studies that identified Pon3 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pon3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pon3 is involved
No pathways found





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