Gene description for Loxl3
Gene name lysyl oxidase-like 3
Gene symbol Loxl3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Loxl3
ExoCarta ExoCarta_312478
Vesiclepedia VP_312478
Entrez Gene 312478
 Loxl3 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Loxl3
Molecular Function
    fibronectin binding GO:0001968 ISO
    protein-lysine 6-oxidase activity GO:0004720 IBA
    protein-lysine 6-oxidase activity GO:0004720 ISO
    copper ion binding GO:0005507 IEA
Biological Process
    epithelial to mesenchymal transition GO:0001837 ISO
    inflammatory response GO:0006954 ISO
    peptidyl-lysine oxidation GO:0018057 ISO
    spinal cord development GO:0021510 ISO
    collagen fibril organization GO:0030199 IBA
    lung development GO:0030324 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
    roof of mouth development GO:0060021 ISO
    somite development GO:0061053 ISO
    fibronectin fibril organization GO:1905590 ISO
    negative regulation of T-helper 17 cell lineage commitment GO:2000329 ISO
    positive regulation of integrin-mediated signaling pathway GO:2001046 ISO
Subcellular Localization
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
    collagen-containing extracellular matrix GO:0062023 IBA
 Experiment description of studies that identified Loxl3 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Loxl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Loxl3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here