Gene description for Rala
Gene name Ras-like protein A
Gene symbol Rala
Other names/aliases 24639550
CG2849
D-RalA
DRal
DRala
Dm RalA
DmelCG2849
Dral
DralA
Drala
P48555
RALA
Ral
Ral-a
RalA
anon-EST:fe1H4
dRal
l(1)G0174
l(1)G0373
l(1)G0501
ral
ralA
Species Drosophila melanogaster
 Database cross references - Rala
ExoCarta ExoCarta_31332
Entrez Gene 31332
UniProt P48555  
 Rala identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Rala
Molecular Function
    GTPase activity GO:0003924 NAS
    PDZ domain binding GO:0030165 IPI
    GTP binding GO:0005525 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of Notch signaling pathway GO:0008593 IGI
    innate immune response GO:0045087 IDA
    regulation of cell morphogenesis GO:0022604 IMP
    Ras protein signal transduction GO:0007265 IGI
    dorsal closure GO:0007391 NAS
    defense response to Gram-negative bacterium GO:0050829 IMP
    negative regulation of innate immune response GO:0045824 IMP
    R3/R4 cell fate commitment GO:0007464 IMP
    border follicle cell migration GO:0007298 IMP
    negative regulation of JNK cascade GO:0046329 TAS
Subcellular Localization
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Rala in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rala
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rala is involved
PathwayEvidenceSource
p38MAPK events IEA Reactome
Translocation of GLUT4 to the plasma membrane IEA Reactome





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