Gene description for Ski
Gene name SKI proto-oncogene
Gene symbol Ski
Other names/aliases RGD1565591
c-ski
Species Rattus norvegicus
 Database cross references - Ski
ExoCarta ExoCarta_313757
Entrez Gene 313757
 Ski identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ski
Molecular Function
    SMAD binding GO:0046332 ISO
    histone deacetylase inhibitor activity GO:0046811 ISO
    chromatin binding GO:0003682 ISO
    protein kinase binding GO:0019901 ISO
    transcription corepressor activity GO:0003714 ISO
    protein domain specific binding GO:0019904 ISO
    zinc ion binding GO:0008270 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    repressing transcription factor binding GO:0070491 ISO
Biological Process
    palate development GO:0060021 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of fibroblast proliferation GO:0048147 ISO
    myelination in peripheral nervous system GO:0022011 ISO
    negative regulation of catalytic activity GO:0043086 ISO
    bone morphogenesis GO:0060349 ISO
    negative regulation of BMP signaling pathway GO:0030514 ISO
    face morphogenesis GO:0060325 ISO
    embryonic limb morphogenesis GO:0030326 ISO
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    negative regulation of Schwann cell proliferation GO:0010626 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    camera-type eye morphogenesis GO:0048593 ISO
    skeletal muscle fiber development GO:0048741 ISO
    neural tube closure GO:0001843 ISO
    protein homotrimerization GO:0070207 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    lens morphogenesis in camera-type eye GO:0002089 ISO
    anterior/posterior axis specification GO:0009948 ISO
    somatic stem cell maintenance GO:0035019 ISO
    positive regulation of DNA binding GO:0043388 ISO
    regulation of apoptotic process GO:0042981 IBA
    camera-type eye development GO:0043010 ISO
    SMAD protein signal transduction GO:0060395 ISO
    retina development in camera-type eye GO:0060041 ISO
    negative regulation of histone deacetylation GO:0031064 ISO
    negative regulation of osteoblast differentiation GO:0045668 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    olfactory bulb development GO:0021772 ISO
    nose morphogenesis GO:0043585 ISO
    negative regulation of activin receptor signaling pathway GO:0032926 ISO
    myotube differentiation GO:0014902 ISO
Subcellular Localization
    PML body GO:0016605 ISO
    protein complex GO:0043234 ISO
    transcription factor complex GO:0005667 ISO
    nuclear body GO:0016604 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 ISO
    transcriptional repressor complex GO:0017053 ISO
 Experiment description of studies that identified Ski in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ski
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ski is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here