Gene description for Spic
Gene name Spi-C transcription factor (Spi-1/PU.1 related)
Gene symbol Spic
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Spic
ExoCarta ExoCarta_314711
Entrez Gene 314711
 Spic identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Spic
Molecular Function
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    blastocyst development GO:0001824 ISO
    cell differentiation GO:0030154 IBA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    transcription from RNA polymerase II promoter GO:0006366 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Spic in exosomes
1
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Spic
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Spic is involved
No pathways found





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