Gene description for Adsl
Gene name adenylosuccinate lyase
Gene symbol Adsl
Other names/aliases null
Species Rattus norvegicus
 Database cross references - Adsl
ExoCarta ExoCarta_315150
Entrez Gene 315150
 Adsl identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Adsl
Molecular Function
    N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0004018 ISO
    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity GO:0070626 IDA
Biological Process
    response to starvation GO:0042594 IEP
    purine nucleotide metabolic process GO:0006163 IMP
    metabolic process GO:0008152 ISO
    'de novo' IMP biosynthetic process GO:0006189 IEA
    response to nutrient GO:0007584 IDA
    response to muscle activity GO:0014850 IEP
    'de novo' AMP biosynthetic process GO:0044208 IEA
    protein tetramerization GO:0051262 ISO
    response to hypoxia GO:0001666 IEP
    aerobic respiration GO:0009060 IMP
    AMP biosynthetic process GO:0006167 ISO
    ribonucleoside monophosphate biosynthetic process GO:0009156 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Adsl in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Adsl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adsl is involved
No pathways found





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