Gene description for Adsl
Gene name adenylosuccinate lyase
Gene symbol Adsl
Other names/aliases null
Species Rattus norvegicus
 Database cross references - Adsl
ExoCarta ExoCarta_315150
Vesiclepedia VP_315150
Entrez Gene 315150
 Adsl identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Adsl
Molecular Function
    N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0004018 IDA
    N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0004018 ISO
    N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0004018 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity GO:0070626 IBA
    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity GO:0070626 IDA
    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity GO:0070626 ISO
Biological Process
    response to hypoxia GO:0001666 IEP
    AMP biosynthetic process GO:0006167 IDA
    AMP biosynthetic process GO:0006167 ISO
    GMP biosynthetic process GO:0006177 ISO
    'de novo' IMP biosynthetic process GO:0006189 IEA
    'de novo' IMP biosynthetic process GO:0006189 ISO
    response to nutrient GO:0007584 IDA
    aerobic respiration GO:0009060 IMP
    response to muscle activity GO:0014850 IEP
    response to starvation GO:0042594 IEP
    'de novo' AMP biosynthetic process GO:0044208 IBA
    'de novo' AMP biosynthetic process GO:0044208 IEA
    'de novo' AMP biosynthetic process GO:0044208 ISO
    AMP salvage GO:0044209 ISO
    'de novo' XMP biosynthetic process GO:0097294 ISO
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Adsl in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Adsl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adsl is involved
No pathways found





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