Gene description for Fbln1
Gene name fibulin 1
Gene symbol Fbln1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fbln1
ExoCarta ExoCarta_315191
Vesiclepedia VP_315191
Entrez Gene 315191
 Fbln1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Fbln1
Molecular Function
    fibronectin binding GO:0001968 ISO
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 ISO
    calcium ion binding GO:0005509 ISO
    peptidase activator activity GO:0016504 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
    fibrinogen binding GO:0070051 ISO
Biological Process
    negative regulation of protein phosphorylation GO:0001933 ISO
    negative regulation of cell adhesion GO:0007162 ISO
    integrin-mediated signaling pathway GO:0007229 ISO
    embryo implantation GO:0007566 IEP
    positive regulation of gene expression GO:0010628 ISO
    extracellular matrix organization GO:0030198 IBA
    extracellular matrix organization GO:0030198 ISO
    positive regulation of fibroblast proliferation GO:0048146 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    negative regulation of transforming growth factor beta production GO:0071635 ISO
    blood coagulation, fibrin clot formation GO:0072378 ISO
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 ISO
    positive regulation of substrate-dependent cell migration, cell attachment to substrate GO:1904237 ISO
    negative regulation of cell motility GO:2000146 ISO
    negative regulation of stem cell proliferation GO:2000647 ISO
Subcellular Localization
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 ISO
    elastic fiber GO:0071953 ISO
 Experiment description of studies that identified Fbln1 in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Fbln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbln1 is involved
No pathways found





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