Gene description for Krt4
Gene name keratin 4, type II
Gene symbol Krt4
Other names/aliases Kb4
Species Rattus norvegicus
 Database cross references - Krt4
ExoCarta ExoCarta_315323
Vesiclepedia VP_315323
Entrez Gene 315323
UniProt Q6IG00  
 Krt4 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Krt4
Molecular Function
    structural constituent of skin epidermis GO:0030280 IBA
Biological Process
    cytoskeleton organization GO:0007010 IEA
    cytoskeleton organization GO:0007010 ISO
    biological_process GO:0008150 ND
    epithelial cell differentiation GO:0030855 IEA
    epithelial cell differentiation GO:0030855 ISO
    epithelial cell differentiation GO:0030855 ISS
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    negative regulation of epithelial cell proliferation GO:0050680 ISO
    negative regulation of epithelial cell proliferation GO:0050680 ISS
Subcellular Localization
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IEA
    keratin filament GO:0045095 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
 Experiment description of studies that identified Krt4 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Krt4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt4 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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