ExoCarta: Gene summary

Credits | Contact

Gene description for Sidt2
Gene name	SID1 transmembrane family, member 2
Gene symbol	Sidt2
Other names/aliases	RGD1308311
Species	Rattus norvegicus
Database cross references - Sidt2
ExoCarta	ExoCarta_315617
Vesiclepedia	VP_315617
Entrez Gene	315617
UniProt	D3ZEH5
Sidt2 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Sidt2

Molecular Function
	DNA binding	GO:0003677	IEA
	double-stranded RNA binding	GO:0003725	IBA
	double-stranded RNA binding	GO:0003725	IEA
	double-stranded RNA binding	GO:0003725	ISO
	AP-2 adaptor complex binding	GO:0035612	IEA
	AP-2 adaptor complex binding	GO:0035612	ISO
	AP-2 adaptor complex binding	GO:0035612	ISS
	AP-1 adaptor complex binding	GO:0035650	IEA
	AP-1 adaptor complex binding	GO:0035650	ISO
	AP-1 adaptor complex binding	GO:0035650	ISS
	nucleic acid transmembrane transporter activity	GO:0051032	IEA
	nucleic acid transmembrane transporter activity	GO:0051032	ISO
	nucleic acid transmembrane transporter activity	GO:0051032	ISS
	RNA transmembrane transporter activity	GO:0051033	IBA
Biological Process
	cell morphogenesis	GO:0000902	IEA
	cell morphogenesis	GO:0000902	ISO
	type B pancreatic cell development	GO:0003323	IEA
	type B pancreatic cell development	GO:0003323	ISO
	RNA catabolic process	GO:0006401	IEA
	RNA catabolic process	GO:0006401	ISO
	RNA catabolic process	GO:0006401	ISS
	response to glucose	GO:0009749	IEA
	response to glucose	GO:0009749	ISO
	glucose homeostasis	GO:0042593	IEA
	glucose homeostasis	GO:0042593	ISO
	type B pancreatic cell proliferation	GO:0044342	IEA
	type B pancreatic cell proliferation	GO:0044342	ISO
	RNA transport	GO:0050658	IBA
	RNA transport	GO:0050658	IEA
	RNA transport	GO:0050658	ISO
	RNA transport	GO:0050658	ISS
	regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	IEA
	regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	ISO
Subcellular Localization
	lysosome	GO:0005764	IBA
	lysosome	GO:0005764	ISO
	lysosome	GO:0005764	ISS
	lysosomal membrane	GO:0005765	IEA
	lysosomal membrane	GO:0005765	ISO
	lysosomal membrane	GO:0005765	ISS
	plasma membrane	GO:0005886	IBA
	plasma membrane	GO:0005886	IEA
	plasma membrane	GO:0005886	ISO
	plasma membrane	GO:0005886	ISS
	membrane	GO:0016020	IEA

Experiment description of studies that identified Sidt2 in sEVs

Experiment ID

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|HSP90\|HSC70\|MHCI	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D2 Rep 2

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting