Gene description for Oxsr1
Gene name oxidative-stress responsive 1
Gene symbol Oxsr1
Other names/aliases Osr1
Species Rattus norvegicus
 Database cross references - Oxsr1
ExoCarta ExoCarta_316064
Vesiclepedia VP_316064
Entrez Gene 316064
 Oxsr1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Oxsr1
Molecular Function
    magnesium ion binding GO:0000287 ISO
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IEA
    protein serine/threonine kinase activity GO:0004674 ISO
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    protein kinase binding GO:0019901 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 ISO
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 ISO
    cell volume homeostasis GO:0006884 ISO
    response to oxidative stress GO:0006979 ISO
    signal transduction GO:0007165 ISO
    osmosensory signaling pathway GO:0007231 ISO
    response to xenobiotic stimulus GO:0009410 ISO
    positive regulation of T cell chemotaxis GO:0010820 IBA
    positive regulation of T cell chemotaxis GO:0010820 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 ISO
    chemokine (C-C motif) ligand 21 signaling pathway GO:0038116 ISO
    chemokine (C-X-C motif) ligand 12 signaling pathway GO:0038146 ISO
    protein autophosphorylation GO:0046777 ISO
    renal sodium ion absorption GO:0070294 ISO
    cellular hyperosmotic response GO:0071474 IBA
    cellular hyperosmotic response GO:0071474 ISO
    cellular hypotonic response GO:0071476 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    cellular response to chemokine GO:1990869 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Oxsr1 in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Oxsr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Oxsr1 is involved
No pathways found





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