Gene description for Oxsr1
Gene name oxidative-stress responsive 1
Gene symbol Oxsr1
Other names/aliases Osr1
Species Rattus norvegicus
 Database cross references - Oxsr1
ExoCarta ExoCarta_316064
Entrez Gene 316064
 Oxsr1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Oxsr1
Molecular Function
    magnesium ion binding GO:0000287 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    ATP binding GO:0005524 ISO
Biological Process
    stress-activated protein kinase signaling cascade GO:0031098 IBA
    negative regulation of rubidium ion transport GO:2000681 ISO
    cellular hypotonic response GO:0071476 ISO
    response to oxidative stress GO:0006979 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    activation of protein kinase activity GO:0032147 IBA
    signal transduction by protein phosphorylation GO:0023014 IBA
    regulation of mitotic cell cycle GO:0007346 IBA
    protein phosphorylation GO:0006468 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    negative regulation of rubidium ion transmembrane transporter activity GO:2000687 ISO
    regulation of apoptotic process GO:0042981 IBA
    intracellular signal transduction GO:0035556 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
Subcellular Localization
    intracellular GO:0005622 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Oxsr1 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Oxsr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Oxsr1 is involved
No pathways found





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