Gene description for Oxsr1
Gene name oxidative-stress responsive 1
Gene symbol Oxsr1
Other names/aliases Osr1
Species Rattus norvegicus
 Database cross references - Oxsr1
ExoCarta ExoCarta_316064
Entrez Gene 316064
 Oxsr1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Oxsr1
Molecular Function
    magnesium ion binding GO:0000287 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    ATP binding GO:0005524 ISO
Biological Process
    stress-activated protein kinase signaling cascade GO:0031098 IBA
    negative regulation of rubidium ion transport GO:2000681 ISO
    cellular hypotonic response GO:0071476 ISO
    response to oxidative stress GO:0006979 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    activation of protein kinase activity GO:0032147 IBA
    signal transduction by protein phosphorylation GO:0023014 IBA
    regulation of mitotic cell cycle GO:0007346 IBA
    protein phosphorylation GO:0006468 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    negative regulation of rubidium ion transmembrane transporter activity GO:2000687 ISO
    regulation of apoptotic process GO:0042981 IBA
    intracellular signal transduction GO:0035556 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
Subcellular Localization
    intracellular GO:0005622 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Oxsr1 in exosomes
Experiment ID 98
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Oxsr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Oxsr1 is involved
No pathways found

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