Gene description for Abhd5
Gene name abhydrolase domain containing 5
Gene symbol Abhd5
Other names/aliases CGI-58
Species Rattus norvegicus
 Database cross references - Abhd5
ExoCarta ExoCarta_316122
Entrez Gene 316122
UniProt Q6QA69  
 Abhd5 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Abhd5
Molecular Function
    lysophosphatidic acid acyltransferase activity GO:0042171 ISO
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 IEA
    triglyceride lipase activity GO:0004806 ISS
    protein binding GO:0005515 IPI
Biological Process
    cell differentiation GO:0030154 IEA
    positive regulation of lipoprotein lipase activity GO:0051006 ISO
    fatty acid metabolic process GO:0006631 IEA
    negative regulation of sequestering of triglyceride GO:0010891 ISS
    positive regulation of triglyceride catabolic process GO:0010898 ISS
    lipid metabolic process GO:0006629 IDA
    phosphatidic acid biosynthetic process GO:0006654 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISS
    intracellular membrane-bounded organelle GO:0043231 ISO
    cytoplasm GO:0005737 ISO
    lipid particle GO:0005811 ISS
 Experiment description of studies that identified Abhd5 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Abhd5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abhd5 is involved
PathwayEvidenceSource
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis IEA Reactome





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