Gene description for Abhd5
Gene name abhydrolase domain containing 5
Gene symbol Abhd5
Other names/aliases CGI-58
Species Rattus norvegicus
 Database cross references - Abhd5
ExoCarta ExoCarta_316122
Vesiclepedia VP_316122
Entrez Gene 316122
UniProt Q6QA69  
 Abhd5 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Abhd5
Molecular Function
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 IEA
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 ISO
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 ISS
    triacylglycerol lipase activity GO:0004806 ISO
    triacylglycerol lipase activity GO:0004806 ISS
    protein binding GO:0005515 IPI
    acyltransferase activity GO:0016746 IEA
    lysophosphatidic acid acyltransferase activity GO:0042171 IBA
    lysophosphatidic acid acyltransferase activity GO:0042171 ISO
    carboxylic ester hydrolase activity GO:0052689 IBA
    lipase activator activity GO:0060229 IEA
    lipase activator activity GO:0060229 ISO
Biological Process
    lipid metabolic process GO:0006629 IDA
    lipid metabolic process GO:0006629 IEA
    fatty acid metabolic process GO:0006631 IEA
    phosphatidic acid biosynthetic process GO:0006654 IBA
    phosphatidic acid biosynthetic process GO:0006654 IEA
    phosphatidic acid biosynthetic process GO:0006654 ISO
    phosphatidic acid biosynthetic process GO:0006654 ISS
    phospholipid biosynthetic process GO:0008654 IEA
    negative regulation of sequestering of triglyceride GO:0010891 IBA
    negative regulation of sequestering of triglyceride GO:0010891 IEA
    negative regulation of sequestering of triglyceride GO:0010891 ISO
    negative regulation of sequestering of triglyceride GO:0010891 ISS
    positive regulation of triglyceride catabolic process GO:0010898 IBA
    positive regulation of triglyceride catabolic process GO:0010898 IEA
    positive regulation of triglyceride catabolic process GO:0010898 ISO
    positive regulation of triglyceride catabolic process GO:0010898 ISS
    cell differentiation GO:0030154 IEA
    positive regulation of lipid catabolic process GO:0050996 ISO
    lipid homeostasis GO:0055088 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 IBA
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 IDA
    lipid droplet GO:0005811 IEA
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Abhd5 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Abhd5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abhd5 is involved
No pathways found





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