Gene description for Brcc3
Gene name	BRCA1/BRCA2-containing complex, subunit 3
Gene symbol	Brcc3
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Brcc3
ExoCarta	ExoCarta_316794
Vesiclepedia	VP_316794
Entrez Gene	316794
UniProt	B2RYM5
Brcc3 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Brcc3

Molecular Function     cysteine-type deubiquitinase activity GO:0004843 IEA     metallopeptidase activity GO:0008237 IBA     metallopeptidase activity GO:0008237 ISO     metallopeptidase activity GO:0008237 ISS     enzyme regulator activity GO:0030234 ISO     polyubiquitin modification-dependent protein binding GO:0031593 IBA     polyubiquitin modification-dependent protein binding GO:0031593 ISO     polyubiquitin modification-dependent protein binding GO:0031593 ISS     metal ion binding GO:0046872 IEA     K63-linked deubiquitinase activity GO:0061578 ISO     metal-dependent deubiquitinase activity GO:0140492 ISO     metal-dependent deubiquitinase activity GO:0140492 ISS Biological Process     double-strand break repair GO:0006302 IBA     double-strand break repair GO:0006302 ISO     double-strand break repair GO:0006302 ISS     chromatin remodeling GO:0006338 ISO     chromatin remodeling GO:0006338 ISS     proteolysis GO:0006508 IEA     mitotic G2 DNA damage checkpoint signaling GO:0007095 ISO     mitotic G2 DNA damage checkpoint signaling GO:0007095 ISS     response to X-ray GO:0010165 ISO     response to ionizing radiation GO:0010212 ISO     response to ionizing radiation GO:0010212 ISS     positive regulation of DNA repair GO:0045739 ISO     positive regulation of DNA repair GO:0045739 ISS     cell division GO:0051301 IEA     protein K63-linked deubiquitination GO:0070536 ISO     protein K63-linked deubiquitination GO:0070536 ISS     cellular response to ionizing radiation GO:0071479 ISO     DNA repair-dependent chromatin remodeling GO:0140861 ISO     DNA repair-dependent chromatin remodeling GO:0140861 ISS     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISS Subcellular Localization     ubiquitin ligase complex GO:0000151 ISO     nuclear ubiquitin ligase complex GO:0000152 ISO     spindle pole GO:0000922 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     BRCA1-A complex GO:0070531 IBA     BRCA1-A complex GO:0070531 ISO     BRCA1-A complex GO:0070531 ISS     BRISC complex GO:0070552 IBA     BRISC complex GO:0070552 ISO     BRISC complex GO:0070552 ISS