Gene description for Usp51
Gene name ubiquitin specific peptidase 51
Gene symbol Usp51
Other names/aliases RGD1562211
Species Rattus norvegicus
 Database cross references - Usp51
ExoCarta ExoCarta_317398
Vesiclepedia VP_317398
Entrez Gene 317398
 Usp51 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Usp51
Molecular Function
    chromatin binding GO:0003682 ISO
    cysteine-type deubiquitinase activity GO:0004843 ISO
    zinc ion binding GO:0008270 IEA
    histone binding GO:0042393 ISO
    histone H2A deubiquitinase activity GO:0140950 ISO
Biological Process
    proteolysis GO:0006508 IEA
    DNA damage response GO:0006974 ISO
    regulation of cell cycle process GO:0010564 ISO
    regulation of double-strand break repair via homologous recombination GO:0010569 ISO
    protein deubiquitination GO:0016579 IEA
    DNA repair-dependent chromatin remodeling GO:0140861 ISO
    regulation of double-strand break repair via nonhomologous end joining GO:2001032 ISO
 Experiment description of studies that identified Usp51 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Usp51
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Usp51 is involved
No pathways found





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