Gene description for ITPR1
Gene name inositol 1,4,5-trisphosphate receptor, type 1
Gene symbol ITPR1
Other names/aliases -
Species Bos taurus
 Database cross references - ITPR1
ExoCarta ExoCarta_317697
Entrez Gene 317697
UniProt Q9TU34  
 ITPR1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ITPR1
Molecular Function
    intracellular ligand-gated calcium channel activity GO:0005218 ISS
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0005220 ISS
    phosphatidylinositol binding GO:0035091 ISS
Biological Process
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    inositol phosphate-mediated signaling GO:0048016 ISS
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    calcium ion transmembrane transport GO:0070588 IEA
Subcellular Localization
    secretory granule GO:0030141 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    transport vesicle membrane GO:0030658 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ITPR1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITPR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ITPR1 is involved
No pathways found





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