Gene description for HIP
Gene name Hsc/Hsp70-interacting protein
Gene symbol HIP
Other names/aliases CG32789
DmelCG32789
anon-EST:fe1A9
Species Drosophila melanogaster
 Database cross references - HIP
ExoCarta ExoCarta_318211
Entrez Gene 318211
UniProt C4NYP8   Q86DS1  
 HIP identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for HIP
Molecular Function
    heat shock protein binding GO:0031072 ISS
    Hsp70 protein binding GO:0030544 ISS
    chaperone binding GO:0051087 ISS
Biological Process
    chaperone cofactor-dependent protein refolding GO:0070389 ISS
Subcellular Localization
    protein complex GO:0043234 ISS
    cytosol GO:0005829 ISS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified HIP in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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