Gene description for Hist1h2ak
Gene name histone cluster 1, H2ak
Gene symbol Hist1h2ak
Other names/aliases -
Species Mus musculus
 Database cross references - Hist1h2ak
ExoCarta ExoCarta_319169
Vesiclepedia VP_319169
Entrez Gene 319169
UniProt Q8CGP7  
 Hist1h2ak identified in sEVs derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Hist1h2ak
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IBA
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    heterochromatin formation GO:0031507 IBA
Subcellular Localization
    nucleosome GO:0000786 IBA
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Hist1h2ak in sEVs
1
Experiment ID 39
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|HSC70|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors "Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G"
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hist1h2ak
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hist1h2ak is involved
PathwayEvidenceSource
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance IEA Reactome
Cleavage of the damaged purine IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
Deposition of new CENPA-containing nucleosomes at the centromere IEA Reactome
Depurination IEA Reactome
Deubiquitination IEA Reactome
DNA Damage/Telomere Stress Induced Senescence IEA Reactome
DNA Repair IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HDACs deacetylate histones IEA Reactome
Inhibition of DNA recombination at telomere IEA Reactome
M Phase IEA Reactome
Metabolism of proteins IEA Reactome
Metalloprotease DUBs IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Nucleosome assembly IEA Reactome
Post-translational protein modification IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
RMTs methylate histone arginines IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Telomere Maintenance IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Ub-specific processing proteases IEA Reactome
UCH proteinases IEA Reactome





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