Gene description for Hist1h2bl
Gene name histone cluster 1, H2bl
Gene symbol Hist1h2bl
Other names/aliases H2b-291a
Species Mus musculus
 Database cross references - Hist1h2bl
ExoCarta ExoCarta_319185
Entrez Gene 319185
UniProt P10853  
 Hist1h2bl identified in exosomes derived from the following tissue/cell type
Dendritic cells 11390481    
Mast cells 17486113    
Oligodendrocytes 21136642    
 Gene ontology annotations for Hist1h2bl
Molecular Function
    DNA binding GO:0003677 IBA
    molecular_function GO:0003674 ND
Biological Process
    defense response to Gram-positive bacterium GO:0050830 ISO
    antibacterial humoral response GO:0019731 ISO
    innate immune response in mucosa GO:0002227 ISO
    nucleosome assembly GO:0006334 IBA
Subcellular Localization
    extracellular space GO:0005615 ISO
    nuclear nucleosome GO:0000788 IBA
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Hist1h2bl in exosomes
1
Experiment ID 10
ISEV standards
EM
EV Biophysical techniques
Alix
EV Cytosolic markers
CD9|MHCII|MHCI|CD86|LAMP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [MALDI TOF]
PubMed ID 11390481    
Organism Mus musculus
Experiment description Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles.
Authors Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S.
Journal name JIMMU
Publication year 2001
Sample Dendritic cells
Sample name D1
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hist1h2bl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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