Gene description for Adgrl3
Gene name adhesion G protein-coupled receptor L3
Gene symbol Adgrl3
Other names/aliases 5430402I23Rik
CIRL-3
D130075K09Rik
Gm1379
LEC3
Lphn3
mKIAA0768
Species Mus musculus
 Database cross references - Adgrl3
ExoCarta ExoCarta_319387
Vesiclepedia VP_319387
Entrez Gene 319387
UniProt Q80TS3  
 Adgrl3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adgrl3
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 IEA
    calcium ion binding GO:0005509 IDA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
Biological Process
    neuron migration GO:0001764 IMP
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    synapse assembly GO:0007416 IBA
    synapse assembly GO:0007416 IDA
    synapse assembly GO:0007416 IMP
    locomotion involved in locomotory behavior GO:0031987 IMP
    response to cocaine GO:0042220 IMP
    synapse organization GO:0050808 IDA
    synapse organization GO:0050808 IMP
    positive regulation of synapse assembly GO:0051965 IDA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IBA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IMP
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 ISO
    maintenance of postsynaptic specialization structure GO:0098880 IDA
    maintenance of postsynaptic specialization structure GO:0098880 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IBA
    cell-cell junction GO:0005911 IDA
    axon GO:0030424 IBA
    axon GO:0030424 IDA
    postsynaptic membrane GO:0045211 IDA
    postsynaptic membrane GO:0045211 IMP
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    glutamatergic synapse GO:0098978 IBA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Adgrl3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adgrl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif5a  
Co-fractionation Mus musculus
2 Zfp191  
Co-fractionation Mus musculus
3 Epm2aip1  
Co-fractionation Mus musculus
4 Lphn1  
Co-fractionation Mus musculus
5 Ncam2  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Adgrl3 is involved
No pathways found





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