Gene description for Chd7
Gene name chromodomain helicase DNA binding protein 7
Gene symbol Chd7
Other names/aliases A730019I05Rik
Cycn
Cyn
Dz
Edy
Flo
GENA 47
GENA 60
Gena 52
Lda
Mt
Obt
Todo
WBE1
Whi
metis
Species Mus musculus
 Database cross references - Chd7
ExoCarta ExoCarta_320790
Entrez Gene 320790
UniProt A2AJK6  
 Chd7 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Chd7
Molecular Function
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    DNA binding GO:0003677 IEA
    hydrolase activity, acting on acid anhydrides GO:0016817 IEA
    chromatin binding GO:0003682 IEA
    hydrolase activity GO:0016787 IEA
    helicase activity GO:0004386 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
Biological Process
    skeletal system development GO:0001501 ISO
    semicircular canal morphogenesis GO:0048752 IGI
    embryonic hindlimb morphogenesis GO:0035116 IMP
    T cell differentiation GO:0030217 ISO
    rRNA processing GO:0006364 IEA
    in utero embryonic development GO:0001701 ISO
    locomotory behavior GO:0007626 IMP
    central nervous system development GO:0007417 ISO
    artery morphogenesis GO:0048844 IGI
    adult heart development GO:0007512 IMP
    transcription, DNA-templated GO:0006351 IEA
    nose development GO:0043584 ISO
    chromatin modification GO:0016568 IEA
    retina development in camera-type eye GO:0060041 ISO
    face development GO:0060324 ISO
    epithelium development GO:0060429 IMP
    genitalia development GO:0048806 ISO
    olfactory nerve development GO:0021553 IMP
    regulation of growth hormone secretion GO:0060123 ISO
    sensory perception of sound GO:0007605 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    blood circulation GO:0008015 IMP
    positive regulation of multicellular organism growth GO:0040018 IMP
    blood vessel development GO:0001568 IMP
    olfactory behavior GO:0042048 IMP
    regulation of neurogenesis GO:0050767 IMP
    olfactory bulb development GO:0021772 IMP
    cranial nerve development GO:0021545 ISO
    inner ear morphogenesis GO:0042472 ISO
    limb development GO:0060173 ISO
    ear morphogenesis GO:0042471 IMP
    cognition GO:0050890 ISO
    palate development GO:0060021 ISO
    heart morphogenesis GO:0003007 ISO
    camera-type eye development GO:0043010 IMP
    female genitalia development GO:0030540 IMP
    adult walking behavior GO:0007628 IMP
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Chd7 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Chd7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Chd7 is involved
No pathways found





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