Gene description for rho-4
Gene name rhomboid-4
Gene symbol rho-4
Other names/aliases CG1697
DmelCG1697
Rho-4
Rho-related [10C6]
rho 4
rho4
Species Drosophila melanogaster
 Database cross references - rho-4
ExoCarta ExoCarta_32109
Entrez Gene 32109
 rho-4 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for rho-4
Molecular Function
    calcium ion binding GO:0005509 IEA
    serine-type peptidase activity GO:0008236 NAS
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    integral component of membrane GO:0016021 NAS
    plasma membrane GO:0005886 NAS
 Experiment description of studies that identified rho-4 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for rho-4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which rho-4 is involved
No pathways found





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