Gene description for ANXA1
Gene name annexin A1
Gene symbol ANXA1
Other names/aliases p35
Species Bos taurus
 Database cross references - ANXA1
ExoCarta ExoCarta_327662
Vesiclepedia VP_327662
Entrez Gene 327662
UniProt P46193  
 ANXA1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ANXA1
Molecular Function
    calcium ion binding GO:0005509 IEA
    calcium-dependent phospholipid binding GO:0005544 IEA
    phospholipase A2 inhibitor activity GO:0019834 IEA
    cadherin binding involved in cell-cell adhesion GO:0098641 IEA
Biological Process
    regulation of leukocyte migration GO:0002685 IEA
    inflammatory response GO:0006954 IEA
    cell surface receptor signaling pathway GO:0007166 IEA
    regulation of cell shape GO:0008360 IEA
    response to X-ray GO:0010165 IEA
    myoblast migration involved in skeletal muscle regeneration GO:0014839 IEA
    actin cytoskeleton organization GO:0030036 IEA
    insulin secretion GO:0030073 IEA
    keratinocyte differentiation GO:0030216 IEA
    prostate gland development GO:0030850 IEA
    endocrine pancreas development GO:0031018 IEA
    positive regulation of vesicle fusion GO:0031340 IEA
    positive regulation of prostaglandin biosynthetic process GO:0031394 IEA
    response to estradiol GO:0032355 IEA
    DNA duplex unwinding GO:0032508 IEA
    regulation of interleukin-1 production GO:0032652 IEA
    positive regulation of interleukin-2 production GO:0032743 IEA
    positive regulation of neutrophil apoptotic process GO:0033031 IEA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IEA
    gliogenesis GO:0042063 IEA
    positive regulation of T cell proliferation GO:0042102 IEA
    response to peptide hormone GO:0043434 IEA
    estrous cycle GO:0044849 IEA
    positive regulation of T-helper 1 cell differentiation GO:0045627 IEA
    negative regulation of T-helper 2 cell differentiation GO:0045629 IEA
    negative regulation of exocytosis GO:0045920 IEA
    alpha-beta T cell differentiation GO:0046632 IEA
    regulation of hormone secretion GO:0046883 IEA
    arachidonate secretion GO:0050482 IEA
    regulation of inflammatory response GO:0050727 IEA
    cellular response to hydrogen peroxide GO:0070301 IEA
    hepatocyte differentiation GO:0070365 IEA
    prolactin secretion GO:0070459 IEA
    response to interleukin-1 GO:0070555 IEA
    cellular response to glucocorticoid stimulus GO:0071385 IEA
    granulocyte chemotaxis GO:0071621 IEA
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA
    positive regulation of wound healing GO:0090303 IEA
    neutrophil clearance GO:0097350 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    negative regulation of phospholipase A2 activity GO:1900138 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ANXA1 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ANXA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANXA1 is involved
No pathways found





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