Gene description for GNB2L1
Gene name guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Gene symbol GNB2L1
Other names/aliases RACK1
Species Bos taurus
 Database cross references - GNB2L1
ExoCarta ExoCarta_327682
Entrez Gene 327682
UniProt P63243  
 GNB2L1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GNB2L1
Molecular Function
    receptor tyrosine kinase binding GO:0030971 ISS
    ion channel inhibitor activity GO:0008200 IEA
    protein tyrosine kinase inhibitor activity GO:0030292 ISS
    protein kinase C binding GO:0005080 ISS
    protein phosphatase binding GO:0019903 IEA
    protein homodimerization activity GO:0042803 IEA
    poly(A) RNA binding GO:0044822 IEA
    SH2 domain binding GO:0042169 ISS
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 IEA
Biological Process
    gastrulation GO:0007369 IEA
    positive regulation of protein homooligomerization GO:0032464 ISS
    positive regulation of GTPase activity GO:0043547 ISS
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of cell migration GO:0030335 ISS
    negative regulation of Wnt signaling pathway GO:0030178 ISS
    regulation of translation GO:0006417 IEA
    regulation of protein localization GO:0032880 ISS
    positive regulation of protein phosphorylation GO:0001934 ISS
    negative regulation of cell growth GO:0030308 ISS
    positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 IEA
    regulation of cell division GO:0051302 ISS
    rhythmic process GO:0048511 IEA
    positive regulation of cAMP catabolic process GO:0030822 IEA
    negative regulation of hydrogen peroxide-induced neuron death GO:1903208 IEA
    positive regulation of apoptotic process GO:0043065 ISS
    cell cycle GO:0007049 IEA
    negative regulation of protein kinase B signaling GO:0051898 IEA
    negative regulation of protein tyrosine kinase activity GO:0061099 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IEA
    positive regulation of gastrulation GO:2000543 ISS
    regulation of establishment of cell polarity GO:2000114 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    regulation of cell cycle GO:0051726 ISS
    negative regulation of phagocytosis GO:0050765 ISS
    positive regulation of mitochondrial depolarization GO:0051901 IEA
Subcellular Localization
    neuronal cell body GO:0043025 ISS
    extracellular exosome GO:0070062 IEA
    perinuclear region of cytoplasm GO:0048471 ISS
    perikaryon GO:0043204 IEA
    dendrite GO:0030425 IEA
    phagocytic cup GO:0001891 ISS
    cytoplasm GO:0005737 ISS
    midbody GO:0030496 ISS
    nucleus GO:0005634 ISS
    mitochondrion GO:0005739 IEA
    cytoskeleton GO:0005856 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified GNB2L1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNB2L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GNB2L1 is involved
No pathways found





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