Gene description for ANXA6
Gene name annexin A6
Gene symbol ANXA6
Other names/aliases -
Species Bos taurus
 Database cross references - ANXA6
ExoCarta ExoCarta_327685
Vesiclepedia VP_327685
Entrez Gene 327685
UniProt P79134  
 ANXA6 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ANXA6
Molecular Function
    ligand-gated ion channel activity GO:0015276 IEA
    calcium-dependent protein binding GO:0048306 IPI
    calcium channel activity GO:0005262 IMP
    cholesterol binding GO:0015485 IEA
    chondroitin sulfate binding GO:0035374 IDA
    phosphatidylserine binding GO:0001786 IPI
    protein homodimerization activity GO:0042803 IEA
    identical protein binding GO:0042802 IPI
    GTP binding GO:0005525 IEA
    calcium-dependent phospholipid binding GO:0005544 IDA
    receptor activity GO:0004872 IDA
    enzyme binding GO:0019899 IPI
    calcium ion binding GO:0005509 IEA
    actin filament binding GO:0051015 IPI
    heparin binding GO:0008201 IDA
Biological Process
    calcium ion transmembrane transport GO:0070588 IDA
    calcium ion transport GO:0006816 ISS
    biomineral tissue development GO:0031214 IDA
    regulation of muscle contraction GO:0006937 ISS
    growth plate cartilage chondrocyte differentiation GO:0003418 IDA
    protein homooligomerization GO:0051260 IEA
    calcium ion import GO:0070509 IMP
    negative regulation of sequestering of calcium ion GO:0051283 IDA
Subcellular Localization
    mitochondrial crista GO:0030061 IDA
    chromaffin granule membrane GO:0042584 IDA
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 IEA
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IDA
    cytosol GO:0005829 IDA
    membrane-bounded vesicle GO:0031988 IDA
    perinuclear region of cytoplasm GO:0048471 ISS
    late endosome membrane GO:0031902 IEA
    melanosome GO:0042470 IEA
    stress fiber GO:0001725 IMP
    integral component of membrane GO:0016021 TAS
    focal adhesion GO:0005925 IMP
 Experiment description of studies that identified ANXA6 in exosomes
1
Experiment ID 213
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ANXA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANXA6 is involved
PathwayEvidenceSource
Muscle contraction IEA Reactome





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