Gene description for EIF2S1
Gene name eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Gene symbol EIF2S1
Other names/aliases -
Species Bos taurus
 Database cross references - EIF2S1
ExoCarta ExoCarta_327694
Entrez Gene 327694
UniProt P68102  
 EIF2S1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for EIF2S1
Molecular Function
    ribosome binding GO:0043022 ISS
    translation initiation factor activity GO:0003743 ISS
    poly(A) RNA binding GO:0044822 IBA
Biological Process
    regulation of translational initiation in response to stress GO:0043558 ISS
    translation GO:0006412 ISS
    protein autophosphorylation GO:0046777 IEA
    translational initiation GO:0006413 IBA
Subcellular Localization
    eukaryotic translation initiation factor 2B complex GO:0005851 ISS
    eukaryotic translation initiation factor 2 complex GO:0005850 IBA
    ribosome GO:0005840 IBA
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 IEA
    multi-eIF complex GO:0043614 IBA
    cytoplasmic stress granule GO:0010494 ISS
    eukaryotic 48S preinitiation complex GO:0033290 IBA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified EIF2S1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EIF2S1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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