Gene description for RAP1B
Gene name RAP1B, member of RAS oncogene family
Gene symbol RAP1B
Other names/aliases -
Species Bos taurus
 Database cross references - RAP1B
ExoCarta ExoCarta_327708
Entrez Gene 327708
UniProt P61223  
 RAP1B identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RAP1B
Molecular Function
    GDP binding GO:0019003 ISS
    GTP binding GO:0005525 ISS
    GTPase activity GO:0003924 ISS
    protein complex binding GO:0032403 IEA
Biological Process
    establishment of endothelial barrier GO:0061028 ISS
    negative regulation of synaptic vesicle exocytosis GO:2000301 IEA
    negative regulation of calcium ion-dependent exocytosis GO:0045955 IEA
    Rap protein signal transduction GO:0032486 ISS
    metabolic process GO:0008152 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    regulation of establishment of cell polarity GO:2000114 ISS
    regulation of cell junction assembly GO:1901888 ISS
    cell proliferation GO:0008283 IEA
    cellular response to cAMP GO:0071320 ISS
Subcellular Localization
    cytosol GO:0005829 IEA
    lipid particle GO:0005811 IEA
    extracellular exosome GO:0070062 IEA
    cell-cell junction GO:0005911 ISS
    membrane GO:0016020 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified RAP1B in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAP1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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