Gene description for Parp4
Gene name poly (ADP-ribose) polymerase family, member 4
Gene symbol Parp4
Other names/aliases Adprtl1
C030027K23Rik
E230037B21Rik
Gm743
PARPL
PH5P
VAULT3
VPARP
p193
Species Mus musculus
 Database cross references - Parp4
ExoCarta ExoCarta_328417
Vesiclepedia VP_328417
Entrez Gene 328417
 Parp4 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Parp4
Molecular Function
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IBA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IEA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 ISO
    nucleotidyltransferase activity GO:0016779 IEA
    enzyme binding GO:0019899 ISO
    NAD+-protein-aspartate ADP-ribosyltransferase activity GO:0140806 IEA
    NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity GO:0140822 IEA
    NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity GO:0140844 IEA
    NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity GO:0140867 IEA
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 ISO
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 ISS
Biological Process
    inflammatory response GO:0006954 IEA
    inflammatory response GO:0006954 ISO
    telomere maintenance via telomerase GO:0007004 IGI
    protein modification process GO:0036211 IEA
    protein modification process GO:0036211 ISO
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    spindle GO:0005819 TAS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    spindle microtubule GO:0005876 IEA
    spindle microtubule GO:0005876 ISO
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified Parp4 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Parp4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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