Gene description for Cdc42
Gene name CG12530 gene product from transcript CG12530-RC
Gene symbol Cdc42
Other names/aliases CDC42
CG12530
Cdc42Dm
D-CDC42
D-Cdc42
D-cdc42
DCDC42
DCdc42
Dcdc42
Dm Cdc42
DmCDC42
Dmcdc42
DmelCG12530
P40793
cdc42
Species Drosophila melanogaster
 Database cross references - Cdc42
ExoCarta ExoCarta_32981
Entrez Gene 32981
UniProt P40793  
 Cdc42 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Cdc42
Molecular Function
    GTPase activity GO:0003924 TAS
    GTPase activating protein binding GO:0032794 IPI
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    maintenance of cell polarity GO:0030011 IMP
    cell projection assembly GO:0030031 IMP
    regulation of actin filament polymerization GO:0030833 IMP
    JNK cascade GO:0007254 TAS
    positive regulation of lamellipodium assembly GO:0010592 IMP
    spermatid development GO:0007286 IMP
    nephrocyte filtration GO:0097206 IMP
    cortical actin cytoskeleton organization GO:0030866 IMP
    cellularization GO:0007349 TAS
    actin filament polymerization GO:0030041 TAS
    dorsal closure GO:0007391 TAS
    positive regulation of wound healing GO:0090303 IMP
    suture of dorsal opening GO:0007396 TAS
    melanotic encapsulation of foreign target GO:0035011 IMP
    dendrite morphogenesis GO:0048813 IMP
    positive regulation of filopodium assembly GO:0051491 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    regulation of axonogenesis GO:0050770 IGI
    dorsal closure, amnioserosa morphology change GO:0046664 IMP
    actin cytoskeleton reorganization GO:0031532 IMP
    epithelium development GO:0060429 IMP
    oogenesis GO:0048477 TAS
    encapsulation of foreign target GO:0035010 IMP
    ovarian follicle cell development GO:0030707 TAS
    dorsal appendage formation GO:0046843 IMP
    actin cytoskeleton organization GO:0030036 TAS
    cytoskeleton organization GO:0007010 NAS
    wound healing GO:0042060 IMP
    actin filament organization GO:0007015 IMP
    branching involved in open tracheal system development GO:0060446 IMP
    sensory perception of touch GO:0050975 IMP
    neuromuscular synaptic transmission GO:0007274 IGI
    imaginal disc-derived wing hair outgrowth GO:0035318 IMP
    exocyst localization GO:0051601 IMP
    hemocyte migration GO:0035099 IMP
    axonogenesis GO:0007409 TAS
    axon guidance GO:0007411 IMP
    regulation of cell shape GO:0008360 IMP
    motor neuron axon guidance GO:0008045 IMP
    phagocytosis GO:0006909 IMP
    neuron projection development GO:0031175 IMP
    vesicle-mediated transport GO:0016192 IMP
    regulation of synaptic growth at neuromuscular junction GO:0008582 IMP
    germarium-derived egg chamber formation GO:0007293 IMP
    protein localization to plasma membrane GO:0072659 IMP
    establishment of neuroblast polarity GO:0045200 IMP
    Rho protein signal transduction GO:0007266 IGI
Subcellular Localization
    cytoplasm GO:0005737 IDA
    rhabdomere GO:0016028 IMP
    axon GO:0030424 IDA
    nucleus GO:0005634 IDA
    apical part of cell GO:0045177 IDA
    cell cortex GO:0005938 IDA
    growth cone GO:0030426 IDA
 Experiment description of studies that identified Cdc42 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cdc42
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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