Gene description for Kctd10
Gene name potassium channel tetramerisation domain containing 10
Gene symbol Kctd10
Other names/aliases AW536343
C87062
mBACURD3
Species Mus musculus
 Database cross references - Kctd10
ExoCarta ExoCarta_330171
Vesiclepedia VP_330171
Entrez Gene 330171
UniProt Q922M3  
 Kctd10 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Kctd10
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IBA
    ubiquitin-protein transferase activity GO:0004842 ISS
    Notch binding GO:0005112 ISO
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
Biological Process
    angiogenesis GO:0001525 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    heart development GO:0007507 IMP
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISS
    negative regulation of Rho protein signal transduction GO:0035024 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    negative regulation of Notch signaling pathway GO:0045746 IMP
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISO
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 ISS
    MKS complex GO:0036038 IDA
    MKS complex GO:0036038 TAS
 Experiment description of studies that identified Kctd10 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Kctd10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Kctd10 is involved
No pathways found





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