Gene description for Taok3
Gene name TAO kinase 3
Gene symbol Taok3
Other names/aliases 2900006A08Rik
A130052D22
A430105I05Rik
Species Mus musculus
 Database cross references - Taok3
ExoCarta ExoCarta_330177
Entrez Gene 330177
UniProt Q8BYC6  
 Taok3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Taok3
Molecular Function
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    kinase activity GO:0016301 IEA
    transferase activity GO:0016740 ISO
    ATP binding GO:0005524 IEA
    nucleotide binding GO:0000166 IEA
    protein kinase activity GO:0004672 IEA
    protein serine/threonine kinase activity GO:0004674 ISO
    MAP kinase kinase kinase activity GO:0004709 IBA
Biological Process
    cellular response to DNA damage stimulus GO:0006974 ISO
    negative regulation of JNK cascade GO:0046329 ISO
    signal transduction by protein phosphorylation GO:0023014 IBA
    protein phosphorylation GO:0006468 ISO
    DNA repair GO:0006281 IEA
    positive regulation of JUN kinase activity GO:0043507 ISO
    mitotic G2 DNA damage checkpoint GO:0007095 ISO
    protein autophosphorylation GO:0046777 ISO
    regulation of mitotic cell cycle GO:0007346 IBA
    stress-activated protein kinase signaling cascade GO:0031098 IBA
    regulation of apoptotic process GO:0042981 IBA
    activation of MAPKK activity GO:0000186 IBA
    positive regulation of stress-activated MAPK cascade GO:0032874 ISO
    MAPK cascade GO:0000165 ISO
    positive regulation of JNK cascade GO:0046330 ISO
    phosphorylation GO:0016310 IEA
Subcellular Localization
    intracellular GO:0005622 ISO
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Taok3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Taok3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Taok3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here