Gene description for l(2)gl
Gene name lethal (2) giant larvae
Gene symbol l(2)gl
Other names/aliases CG2671
D-LGL
DmelCG2671
L(2)GL
L(2)gl
LGL
Lgl
MENE (2L)-B
dlgl
gl
l(2)
l(2) giant larva
l(2)giant larvae
l-gl
l[[2]]gl
lgl
p127
p127[l(2)gl]
p127l(2)gl
Species Drosophila melanogaster
 Database cross references - l(2)gl
ExoCarta ExoCarta_33156
Vesiclepedia VP_33156
Entrez Gene 33156
UniProt P08111  
 l(2)gl identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for l(2)gl
Molecular Function
    SNARE binding GO:0000149 IPI
    protein kinase inhibitor activity GO:0004860 IDA
    myosin binding GO:0017022 IGI
    protein kinase binding GO:0019901 IPI
    myosin II binding GO:0045159 IGI
Biological Process
    establishment of mitotic spindle orientation GO:0000132 IMP
    oocyte anterior/posterior axis specification GO:0007314 IMP
    dorsal closure GO:0007391 TAS
    nervous system development GO:0007399 IMP
    negative regulation of neuroblast proliferation GO:0007406 IMP
    sensory organ development GO:0007423 IMP
    oocyte microtubule cytoskeleton organization GO:0016325 IMP
    morphogenesis of follicular epithelium GO:0016333 IMP
    establishment or maintenance of polarity of follicular epithelium GO:0016334 IGI
    sensory organ precursor cell fate determination GO:0016360 IMP
    septate junction assembly GO:0019991 TAS
    actin cytoskeleton organization GO:0030036 IMP
    salivary gland histolysis GO:0035070 IMP
    cell competition in a multicellular organism GO:0035212 IMP
    chitin-based larval cuticle pattern formation GO:0035293 IMP
    positive regulation of hippo signaling GO:0035332 IGI
    positive regulation of hippo signaling GO:0035332 IMP
    asymmetric protein localization involved in cell fate determination GO:0045167 IMP
    asymmetric protein localization involved in cell fate determination GO:0045167 IPI
    basal protein localization GO:0045175 IGI
    basal protein localization GO:0045175 IMP
    apical protein localization GO:0045176 IMP
    establishment of protein localization GO:0045184 IMP
    establishment or maintenance of neuroblast polarity GO:0045196 IGI
    R8 cell fate specification GO:0045464 IMP
    negative regulation of imaginal disc growth GO:0045571 IMP
    negative regulation of Notch signaling pathway GO:0045746 IGI
    negative regulation of Notch signaling pathway GO:0045746 IMP
    autophagic cell death GO:0048102 IMP
    epidermis morphogenesis GO:0048730 IMP
    localization within membrane GO:0051668 IMP
    asymmetric neuroblast division GO:0055059 IGI
    protein localization to cell cortex GO:0072697 IMP
    establishment of epithelial cell planar polarity GO:0090163 IMP
    symmetric cell division GO:0098725 IMP
    regulation of intracellular mRNA localization GO:1904580 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 HDA
    plasma membrane GO:0005886 IDA
    smooth septate junction GO:0005920 IDA
    cell cortex GO:0005938 IDA
    apicolateral plasma membrane GO:0016327 IDA
    cortical cytoskeleton GO:0030863 IDA
    extracellular matrix GO:0031012 IDA
    leading edge membrane GO:0031256 IDA
    presynaptic membrane GO:0042734 IDA
 Experiment description of studies that identified l(2)gl in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for l(2)gl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG17568  
Two-hybrid Drosophila melanogaster
2 par-6  
Affinity Capture-Western Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
3 CycE  
Phenotypic Suppression Drosophila melanogaster
4 ctp  
Two-hybrid Drosophila melanogaster
5 CG18748  
Affinity Capture-MS Drosophila melanogaster
6 Ssu72  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which l(2)gl is involved
No pathways found





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