Gene description for l(2)gl
Gene name lethal (2) giant larvae
Gene symbol l(2)gl
Other names/aliases CG2671
D-LGL
DmelCG2671
L(2)GL
L(2)gl
LGL
Lgl
MENE (2L)-B
dlgl
gl
l(2)
l(2) giant larva
l(2)giant larvae
l-gl
l[[2]]gl
lgl
p127
p127[l(2)gl]
p127l(2)gl
Species Drosophila melanogaster
 Database cross references - l(2)gl
ExoCarta ExoCarta_33156
Entrez Gene 33156
UniProt P08111  
 l(2)gl identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for l(2)gl
Molecular Function
    myosin II binding GO:0045159 TAS
    myosin binding GO:0017022 IGI
    SNARE binding GO:0000149 IPI
    protein kinase inhibitor activity GO:0004860 IDA
Biological Process
    germarium-derived egg chamber formation GO:0007293 IMP
    negative regulation of protein kinase activity GO:0006469 IDA
    morphogenesis of an epithelium GO:0002009 TAS
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 TAS
    establishment of epithelial cell planar polarity GO:0090163 IMP
    basal protein localization GO:0045175 NAS
    synaptic vesicle priming GO:0016082 NAS
    ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072 NAS
    epidermis morphogenesis GO:0048730 IMP
    regulation of cell cycle GO:0051726 NAS
    establishment or maintenance of polarity of follicular epithelium GO:0016334 IGI
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    negative regulation of neuroblast proliferation GO:0007406 IMP
    septate junction assembly GO:0019991 TAS
    establishment of neuroblast polarity GO:0045200 TAS
    oocyte anterior/posterior axis specification GO:0007314 IMP
    morphogenesis of follicular epithelium GO:0016333 IMP
    salivary gland histolysis GO:0035070 IMP
    negative regulation of cell proliferation GO:0008285 TAS
    establishment of protein localization GO:0045184 IMP
    establishment of mitotic spindle orientation GO:0000132 IMP
    asymmetric neuroblast division GO:0055059 IGI
    cell proliferation GO:0008283 TAS
    localization within membrane GO:0051668 IMP
    establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 TAS
    establishment or maintenance of polarity of embryonic epithelium GO:0016332 TAS
    protein localization GO:0008104 TAS
    morphogenesis of larval imaginal disc epithelium GO:0016335 TAS
    dorsal closure GO:0007391 TAS
    histolysis GO:0007559 NAS
    morphogenesis of a polarized epithelium GO:0001738 TAS
    sensory organ development GO:0007423 IMP
    asymmetric protein localization involved in cell fate determination GO:0045167 TAS
    cell differentiation GO:0030154 NAS
    cell competition in a multicellular organism GO:0035212 IMP
    asymmetric protein localization GO:0008105 TAS
    actin cytoskeleton organization GO:0030036 IMP
    chitin-based larval cuticle pattern formation GO:0035293 IMP
    oocyte microtubule cytoskeleton organization GO:0016325 IMP
    neurotransmitter secretion GO:0007269 NAS
    regulation of cell shape GO:0008360 NAS
    epithelium development GO:0060429 IMP
    nervous system development GO:0007399 IMP
    negative regulation of Notch signaling pathway GO:0045746 IGI
    regulation of cell proliferation GO:0042127 NAS
    establishment or maintenance of neuroblast polarity GO:0045196 TAS
    symmetric cell division GO:0098725 IMP
Subcellular Localization
    cortical cytoskeleton GO:0030863 IDA
    proteinaceous extracellular matrix GO:0005578 IDA
    cytoskeleton GO:0005856 NAS
    plasma membrane GO:0005886 TAS
    synaptic vesicle GO:0008021 NAS
    apicolateral plasma membrane GO:0016327 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    basolateral plasma membrane GO:0016323 TAS
    septate junction GO:0005918 TAS
    cell cortex GO:0005938 TAS
    smooth septate junction GO:0005920 IDA
    interstitial matrix GO:0005614 NAS
 Experiment description of studies that identified l(2)gl in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for l(2)gl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which l(2)gl is involved
No pathways found





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