Gene description for AP-2alpha
Gene name Adaptor Protein complex 2, alpha subunit
Gene symbol AP-2alpha
Other names/aliases AP-2
AP2
Alpha-Adaptin
CG31654
CG4260
D-Ada
D-alphaAda
DmelCG4260
MENE (2L)-A
MENE(2L)-A
ada
alpha
alpha-Ada
alpha-Adaptin
alpha-ada
alpha-adaptin
apl3
cg4260
dAP-2a
l(2)06694
l(2)SH0460
l(2)SH2 0460
Species Drosophila melanogaster
 Database cross references - AP-2alpha
ExoCarta ExoCarta_33211
Entrez Gene 33211
UniProt P91926  
 AP-2alpha identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for AP-2alpha
Molecular Function
    protein transporter activity GO:0008565 IMP
Biological Process
    synaptic vesicle coating GO:0016183 TAS
    vesicle coating GO:0006901 TAS
    protein localization GO:0008104 IMP
    neurotransmitter secretion GO:0007269 NAS
    neurogenesis GO:0022008 IMP
    vesicle-mediated transport GO:0016192 NAS
    synaptic vesicle transport GO:0048489 TAS
    intracellular protein transport GO:0006886 IEA
    endocytosis GO:0006897 IMP
    positive regulation of endocytosis GO:0045807 IMP
    asymmetric cell division GO:0008356 TAS
    regulation of endocytosis GO:0030100 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    AP-2 adaptor complex GO:0030122 NAS
    coated vesicle GO:0030135 TAS
    synaptic vesicle GO:0008021 TAS
 Experiment description of studies that identified AP-2alpha in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AP-2alpha
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AP-2alpha is involved
No pathways found





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