Gene description for P2RX4
Gene name purinergic receptor P2X, ligand-gated ion channel, 4
Gene symbol P2RX4
Other names/aliases -
Species Bos taurus
 Database cross references - P2RX4
ExoCarta ExoCarta_338036
Entrez Gene 338036
UniProt Q5E9U1  
 P2RX4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for P2RX4
Molecular Function
    extracellular ATP-gated cation channel activity GO:0004931 ISS
    purinergic nucleotide receptor activity GO:0001614 IBA
    ATP binding GO:0005524 IEA
    cadherin binding GO:0045296 IEA
Biological Process
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    cellular response to ATP GO:0071318 ISS
    nitric oxide biosynthetic process GO:0006809 IEA
    negative regulation of cardiac muscle hypertrophy GO:0010614 IEA
    purinergic nucleotide receptor signaling pathway GO:0035590 IEA
    response to fluid shear stress GO:0034405 IEA
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    apoptotic signaling pathway GO:0097190 IEA
    calcium ion transport GO:0006816 IEA
    regulation of cardiac muscle contraction GO:0055117 IEA
    ion transmembrane transport GO:0034220 ISS
    positive regulation of calcium ion transport into cytosol GO:0010524 IEA
    cation transport GO:0006812 IBA
    regulation of blood pressure GO:0008217 IEA
    relaxation of cardiac muscle GO:0055119 IEA
    vasodilation GO:0042311 IEA
    cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    extracellular exosome GO:0070062 IEA
    lysosomal membrane GO:0005765 IEA
    integral component of nuclear inner membrane GO:0005639 IBA
    apical part of cell GO:0045177 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    integral component of plasma membrane GO:0005887 ISS
 Experiment description of studies that identified P2RX4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which P2RX4 is involved
No pathways found





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