Gene description for P2RX4
Gene name purinergic receptor P2X, ligand-gated ion channel, 4
Gene symbol P2RX4
Other names/aliases -
Species Bos taurus
 Database cross references - P2RX4
ExoCarta ExoCarta_338036
Vesiclepedia VP_338036
Entrez Gene 338036
UniProt Q5E9U1  
 P2RX4 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for P2RX4
Molecular Function
    purinergic nucleotide receptor activity GO:0001614 IEA
    extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IEA
    ATP binding GO:0005524 IEA
Biological Process
    response to ATP GO:0033198 IEA
    monoatomic cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    nuclear inner membrane GO:0005637 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified P2RX4 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which P2RX4 is involved
PathwayEvidenceSource
Elevation of cytosolic Ca2+ levels IEA Reactome
Hemostasis IEA Reactome
Platelet calcium homeostasis IEA Reactome
Platelet homeostasis IEA Reactome





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