Gene description for SERPINA5
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Gene symbol SERPINA5
Other names/aliases -
Species Bos taurus
 Database cross references - SERPINA5
ExoCarta ExoCarta_338050
Entrez Gene 338050
UniProt Q9N2I2  
 SERPINA5 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for SERPINA5
Molecular Function
    retinoic acid binding GO:0001972 ISS
    heparin binding GO:0008201 IEA
    phosphatidylcholine binding GO:0031210 ISS
    protease binding GO:0002020 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 ISS
    acrosin binding GO:0032190 IEA
Biological Process
    single fertilization GO:0007338 IEA
    lipid transport GO:0006869 IEA
    negative regulation of endopeptidase activity GO:0010951 IBA
    spermatogenesis GO:0007283 IEA
Subcellular Localization
    protein C inhibitor-coagulation factor XI complex GO:0097183 ISS
    protein C inhibitor-coagulation factor Xa complex GO:0097182 ISS
    protein C inhibitor-KLK3 complex GO:0036029 ISS
    external side of plasma membrane GO:0009897 IEA
    protein C inhibitor-TMPRSS7 complex GO:0036024 ISS
    extracellular space GO:0005615 ISS
    platelet alpha granule GO:0031091 ISS
    protein C inhibitor-plasma kallikrein complex GO:0036030 ISS
    platelet dense tubular network GO:0031094 ISS
    protein C inhibitor-TMPRSS11E complex GO:0036025 ISS
    protein C inhibitor-thrombin complex GO:0036028 ISS
    protein C inhibitor-PLAT complex GO:0036026 ISS
    acrosomal membrane GO:0002080 ISS
    protein C inhibitor-coagulation factor V complex GO:0097181 ISS
    extracellular exosome GO:0070062 IEA
    protein C inhibitor-PLAU complex GO:0036027 ISS
 Experiment description of studies that identified SERPINA5 in exosomes
1
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINA5 is involved
PathwayEvidenceSource
Common Pathway of Fibrin Clot Formation IEA Reactome
Intrinsic Pathway of Fibrin Clot Formation IEA Reactome





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