Gene description for CAPZB
Gene name capping protein (actin filament) muscle Z-line, beta
Gene symbol CAPZB
Other names/aliases -
Species Bos taurus
 Database cross references - CAPZB
ExoCarta ExoCarta_338052
Entrez Gene 338052
UniProt P79136  
 CAPZB identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CAPZB
Molecular Function
    actin filament binding GO:0051015 IBA
    beta-tubulin binding GO:0048487 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of cell morphogenesis GO:0022604 ISS
    barbed-end actin filament capping GO:0051016 IBA
    cytoskeleton organization GO:0007010 ISS
    actin cytoskeleton organization GO:0030036 IEA
    regulation of lamellipodium assembly GO:0010591 IBA
    neuron projection development GO:0031175 IEA
    regulation of protein kinase C signaling GO:0090036 IEA
    muscle fiber development GO:0048747 IEA
    negative regulation of microtubule polymerization GO:0031115 IEA
    negative regulation of filopodium assembly GO:0051490 IBA
    lamellipodium assembly GO:0030032 IEA
    cell morphogenesis GO:0000902 IBA
Subcellular Localization
    Z disc GO:0030018 IEA
    membrane GO:0016020 IEA
    lamellipodium GO:0030027 IEA
    acrosomal vesicle GO:0001669 IEA
    cytoskeletal calyx GO:0033150 IEA
    actin filament GO:0005884 IBA
    WASH complex GO:0071203 ISS
    F-actin capping protein complex GO:0008290 IBA
    intercalated disc GO:0014704 IEA
    cortical cytoskeleton GO:0030863 IEA
 Experiment description of studies that identified CAPZB in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAPZB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CAPZB is involved
Factors involved in megakaryocyte development and platelet production IEA Reactome

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