Gene description for ARHGDIA
Gene name Rho GDP dissociation inhibitor (GDI) alpha
Gene symbol ARHGDIA
Other names/aliases -
Species Bos taurus
 Database cross references - ARHGDIA
ExoCarta ExoCarta_338054
Entrez Gene 338054
UniProt P19803  
 ARHGDIA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ARHGDIA
Molecular Function
    Rho GDP-dissociation inhibitor activity GO:0005094 ISS
    GTPase activator activity GO:0005096 IEA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    regulation of protein localization GO:0032880 IEA
    Rho protein signal transduction GO:0007266 ISS
    semaphorin-plexin signaling pathway GO:0071526 ISS
Subcellular Localization
    immunological synapse GO:0001772 ISS
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified ARHGDIA in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARHGDIA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARHGDIA is involved
PathwayEvidenceSource
Axonal growth inhibition (RHOA activation) IEA Reactome
Axonal growth stimulation IEA Reactome
Rho GTPase cycle IEA Reactome





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