Gene description for wg
Gene name wingless
Gene symbol wg
Other names/aliases Br
CG4889
DWint-1
DWnt-1
Dint-1
Dm Wg
Dm-1
DmelCG4889
Gla
I
Sp
WG
WNT
Wg
Wnt
Wnt-1
Wnt/Wg
Wnt1
dWnt
fg
int-1
l(2)02657
l(2)rO727
l(2)wg
spd
wgl
wnt
wnt1
Species Drosophila melanogaster
 Database cross references - wg
ExoCarta ExoCarta_34009
Entrez Gene 34009
UniProt P09615  
 wg identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for wg
Molecular Function
    frizzled-2 binding GO:0005110 IPI
    receptor binding GO:0005102 NAS
    glycosaminoglycan binding GO:0005539 IDA
    protein binding GO:0005515 IPI
    morphogen activity GO:0016015 TAS
    heparan sulfate proteoglycan binding GO:0043395 IPI
    extracellular matrix binding GO:0050840 IDA
    frizzled binding GO:0005109 IPI
    Notch binding GO:0005112 TAS
Biological Process
    Malpighian tubule bud morphogenesis GO:0061332 IMP
    mesoderm development GO:0007498 IMP
    positive regulation of compound eye retinal cell programmed cell death GO:0046672 IMP
    spiracle morphogenesis, open tracheal system GO:0035277 IMP
    leg disc proximal/distal pattern formation GO:0007479 TAS
    canonical Wnt signaling pathway GO:0060070 IGI
    regulation of mitotic cell cycle GO:0007346 TAS
    Wnt signaling pathway, calcium modulating pathway GO:0007223 IGI
    sensory organ development GO:0007423 TAS
    wing cell fate specification GO:0035311 IMP
    proboscis development GO:0048728 IMP
    Wnt signaling pathway GO:0016055 NAS
    epidermis development GO:0008544 IMP
    regulation of imaginal disc-derived wing size GO:0044719 IMP
    dorsal/ventral pattern formation, imaginal disc GO:0007450 TAS
    ectoderm development GO:0007398 IMP
    negative regulation of hemocyte differentiation GO:0045611 IMP
    branch fusion, open tracheal system GO:0035147 IMP
    filopodium assembly GO:0046847 IMP
    cardioblast differentiation GO:0010002 IMP
    genital disc development GO:0035215 TAS
    ommatidial rotation GO:0016318 TAS
    trunk segmentation GO:0035290 TAS
    genital disc sexually dimorphic development GO:0035263 IMP
    axis specification GO:0009798 IBA
    midbrain-hindbrain boundary development GO:0030917 IBA
    negative regulation of phosphorylation GO:0042326 NAS
    negative regulation of apoptotic process GO:0043066 TAS
    regulation of stem cell proliferation GO:0072091 IMP
    synaptic growth at neuromuscular junction GO:0051124 IMP
    hindgut morphogenesis GO:0007442 IMP
    synapse organization GO:0050808 IMP
    positive regulation of crystal cell differentiation GO:0042691 IMP
    instar larval development GO:0002168 TAS
    ventral midline development GO:0007418 IMP
    segment polarity determination GO:0007367 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    lymph gland development GO:0048542 IMP
    genital disc anterior/posterior pattern formation GO:0035224 IEP
    epithelial cell proliferation involved in Malpighian tubule morphogenesis GO:0061331 IMP
    positive regulation of cell proliferation GO:0008284 IMP
    Malpighian tubule tip cell differentiation GO:0061382 IMP
    larval lymph gland hemopoiesis GO:0035167 IMP
    imaginal disc growth GO:0007446 TAS
    cuticle pattern formation GO:0035017 IMP
    long-term memory GO:0007616 IMP
    positive regulation of stem cell proliferation GO:2000648 IMP
    posterior head segmentation GO:0035289 TAS
    negative regulation of DNA endoreduplication GO:0032876 IMP
    negative regulation of fat cell differentiation GO:0045599 IBA
    negative regulation of cell fate specification GO:0009996 IMP
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    actin filament bundle assembly GO:0051017 IMP
    imaginal disc development GO:0007444 IMP
    dorsal closure GO:0007391 IMP
    dorsal closure, elongation of leading edge cells GO:0007394 IMP
    mesoderm morphogenesis GO:0048332 IMP
    epithelial cell type specification, open tracheal system GO:0035153 IMP
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    compound eye morphogenesis GO:0001745 IMP
    neuroblast development GO:0014019 IMP
    regulation of cell proliferation GO:0042127 NAS
    wing disc dorsal/ventral pattern formation GO:0048190 TAS
    branching morphogenesis of an epithelial tube GO:0048754 IMP
    wing disc development GO:0035220 IGI
    regulation of transcription, DNA-templated GO:0006355 IMP
    anterior head segmentation GO:0035288 TAS
    heart development GO:0007507 IMP
    lamellipodium assembly GO:0030032 IMP
    heart formation GO:0060914 IMP
    posterior Malpighian tubule development GO:0061328 IMP
    pericardial nephrocyte differentiation GO:0061320 IMP
    negative regulation of heart induction by canonical Wnt signaling pathway GO:0003136 IMP
    lymph gland crystal cell differentiation GO:0035170 IMP
    anterior/posterior pattern specification, imaginal disc GO:0007448 IMP
    larval visceral muscle development GO:0007523 IMP
    ovarian follicle cell development GO:0030707 IMP
    somatic stem cell maintenance GO:0035019 IBA
    determination of genital disc primordium GO:0035225 IMP
    anterior/posterior axis specification, embryo GO:0008595 TAS
    ventral cord development GO:0007419 TAS
    compound eye development GO:0048749 TAS
    regulation of compound eye pigmentation GO:0048076 IMP
    labial disc development GO:0035217 IMP
    imaginal disc pattern formation GO:0007447 TAS
Subcellular Localization
    multivesicular body GO:0005771 IDA
    extracellular region GO:0005576 TAS
    terminal bouton GO:0043195 IDA
    plasma membrane GO:0005886 IDA
    late endosome GO:0005770 IDA
    membrane raft GO:0045121 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 NAS
    extracellular space GO:0005615 IDA
    early endosome GO:0005769 IDA
    endocytic vesicle GO:0030139 IDA
    endoplasmic reticulum GO:0005783 IDA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified wg in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for wg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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