Gene description for SLC35D3
Gene name solute carrier family 35, member D3
Gene symbol SLC35D3
Other names/aliases FRCL1
Species Homo sapiens
 Database cross references - SLC35D3
ExoCarta ExoCarta_340146
Entrez Gene 340146
HGNC 15621
MIM 612519
UniProt Q5M8T2  
 SLC35D3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SLC35D3
Molecular Function
    pyrimidine nucleotide-sugar transmembrane transporter activity GO:0015165 IBA
    antiporter activity GO:0015297 IBA
Biological Process
    anion transmembrane transport GO:0098656 IBA
    carbohydrate transmembrane transport GO:0034219 IBA
    pyrimidine nucleotide-sugar transmembrane transport GO:0090481 IBA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC35D3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SLC35D3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC35D3 is involved
No pathways found





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