Gene description for PKD1L3
Gene name polycystic kidney disease 1-like 3
Gene symbol PKD1L3
Other names/aliases -
Species Homo sapiens
 Database cross references - PKD1L3
ExoCarta ExoCarta_342372
Entrez Gene 342372
HGNC 21716
MIM 607895
UniProt Q7Z443  
 PKD1L3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PKD1L3
Molecular Function
    sour taste receptor activity GO:0033040 ISS
    cation transmembrane transporter activity GO:0008324 ISS
    calcium channel activity GO:0005262 IEA
    carbohydrate binding GO:0030246 IEA
    cation channel activity GO:0005261 ISS
    protein binding GO:0005515 IPI
Biological Process
    kidney development GO:0001822 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    cation transport GO:0006812 ISS
    cellular response to acidic pH GO:0071468 ISS
    detection of chemical stimulus involved in sensory perception of sour taste GO:0001581 ISS
    sensory perception of sour taste GO:0050915 IMP
Subcellular Localization
    cation channel complex GO:0034703 ISS
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 ISS
    extracellular exosome GO:0070062 IDA
    receptor complex GO:0043235 ISS
 Experiment description of studies that identified PKD1L3 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PKD1L3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VHL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PKD1L3 is involved
No pathways found





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