Gene description for PKD1L3
Gene name polycystic kidney disease 1-like 3
Gene symbol PKD1L3
Other names/aliases -
Species Homo sapiens
 Database cross references - PKD1L3
ExoCarta ExoCarta_342372
Vesiclepedia VP_342372
Entrez Gene 342372
HGNC 21716
MIM 607895
UniProt Q7Z443  
 PKD1L3 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PKD1L3
Molecular Function
    calcium-activated cation channel activity GO:0005227 ISS
    monoatomic cation channel activity GO:0005261 ISS
    calcium channel activity GO:0005262 IBA
    protein binding GO:0005515 IPI
    monoatomic cation transmembrane transporter activity GO:0008324 ISS
    carbohydrate binding GO:0030246 IEA
    sour taste receptor activity GO:0033040 ISS
    sour taste receptor activity GO:0033040 ISS
    pH-gated monoatomic ion channel activity GO:0160128 IDA
Biological Process
    detection of chemical stimulus involved in sensory perception of sour taste GO:0001581 ISS
    detection of chemical stimulus involved in sensory perception of sour taste GO:0001581 ISS
    monoatomic cation transport GO:0006812 ISS
    sensory perception of sour taste GO:0050915 IMP
    detection of mechanical stimulus GO:0050982 IBA
    calcium ion transmembrane transport GO:0070588 IDA
    cellular response to acidic pH GO:0071468 ISS
    cellular response to acidic pH GO:0071468 ISS
    monoatomic cation transmembrane transport GO:0098655 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 ISS
    membrane GO:0016020 IBA
    cation channel complex GO:0034703 ISS
    receptor complex GO:0043235 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PKD1L3 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PKD1L3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pparg  
Affinity Capture-MS Mus musculus
2 VHL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PKD1L3 is involved
No pathways found





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