Gene description for Stam
Gene name Signal transducing adaptor molecule
Gene symbol Stam
Other names/aliases CG6521
DmelCG6521
Dstam
STAM
Stam1
dstam
stam
Species Drosophila melanogaster
 Database cross references - Stam
ExoCarta ExoCarta_34505
Entrez Gene 34505
 Stam identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Stam
Molecular Function
    ubiquitin binding GO:0043130 ISS
    JAK pathway signal transduction adaptor activity GO:0008269 NAS
Biological Process
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    JAK-STAT cascade GO:0007259 NAS
    regulation of JAK-STAT cascade GO:0046425 TAS
    synaptic vesicle endocytosis GO:0048488 NAS
    neuron remodeling GO:0016322 IGI
    regulation of epithelial cell migration, open tracheal system GO:2000274 IMP
    wound healing GO:0042060 IMP
    intracellular protein transport GO:0006886 IEA
    neurotransmitter secretion GO:0007269 NAS
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IMP
    epithelial cell migration, open tracheal system GO:0007427 IMP
    regulation of cell cycle GO:0051726 IGI
    endosomal transport GO:0016197 ISS
Subcellular Localization
    ESCRT-0 complex GO:0033565 ISS
 Experiment description of studies that identified Stam in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Stam
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Stam is involved
No pathways found





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