Gene description for kuz
Gene name kuzbanian
Gene symbol kuz
Other names/aliases 11410
34Da
ADAM10
BG:DS07660.3
CG7147
CT22079
DmelCG7147
GS11410
Kuz
br38
l(2)03782
l(2)34Da
l(2)br38
l(2)c00136
l(2)k01403
l34Da
soy nut
Species Drosophila melanogaster
 Database cross references - kuz
ExoCarta ExoCarta_34772
Entrez Gene 34772
 kuz identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for kuz
Molecular Function
    zinc ion binding GO:0008270 IEA
    metalloendopeptidase activity GO:0004222 ISS
Biological Process
    axon guidance GO:0007411 IMP
    glial cell migration GO:0008347 IMP
    Notch receptor processing GO:0007220 IGI
    skeletal muscle tissue development GO:0007519 IMP
    regulation of axon extension GO:0030516 TAS
    membrane protein ectodomain proteolysis GO:0006509 ISS
    neuroblast fate determination GO:0007400 IDA
    border follicle cell migration GO:0007298 IMP
    Notch signaling pathway GO:0007219 TAS
    heart morphogenesis GO:0003007 IMP
    phagocytosis GO:0006909 IMP
    lymph gland development GO:0048542 IMP
    muscle tissue development GO:0060537 IMP
    oogenesis GO:0048477 IMP
    cardiocyte differentiation GO:0035051 IMP
    pericardial nephrocyte differentiation GO:0061320 IMP
    regulation of Roundabout signaling pathway GO:0035386 IGI
    central nervous system development GO:0007417 TAS
Subcellular Localization
    integral component of membrane GO:0016021 ISS
    perivitelline space GO:0098595 IDA
 Experiment description of studies that identified kuz in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for kuz
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which kuz is involved
No pathways found





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