Gene description for kuz
Gene name kuzbanian
Gene symbol kuz
Other names/aliases 11410
34Da
ADAM10
BG:DS07660.3
CG7147
CT22079
DmelCG7147
GS11410
Kuz
br38
l(2)03782
l(2)34Da
l(2)br38
l(2)c00136
l(2)k01403
l34Da
soy nut
Species Drosophila melanogaster
 Database cross references - kuz
ExoCarta ExoCarta_34772
Vesiclepedia VP_34772
Entrez Gene 34772
 kuz identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for kuz
Molecular Function
    metalloendopeptidase activity GO:0004222 IDA
    metalloendopeptidase activity GO:0004222 IMP
Biological Process
    heart morphogenesis GO:0003007 IMP
    membrane protein ectodomain proteolysis GO:0006509 IDA
    Notch signaling pathway GO:0007219 IGI
    Notch signaling pathway GO:0007219 IMP
    Notch receptor processing GO:0007220 IDA
    Notch receptor processing GO:0007220 IMP
    border follicle cell migration GO:0007298 IMP
    neuroblast fate determination GO:0007400 IDA
    axon guidance GO:0007411 IMP
    central nervous system development GO:0007417 TAS
    ventral cord development GO:0007419 HMP
    ventral cord development GO:0007419 IMP
    glial cell migration GO:0008347 IMP
    regulation of axon extension GO:0030516 TAS
    cardiocyte differentiation GO:0035051 IMP
    regulation of Roundabout signaling pathway GO:0035386 IGI
    oogenesis GO:0048477 IMP
    lymph gland development GO:0048542 IMP
    muscle tissue development GO:0060537 IMP
    pericardial nephrocyte differentiation GO:0061320 IMP
    positive regulation of border follicle cell migration GO:1903688 IMP
Subcellular Localization
    perivitelline space GO:0098595 HDA
 Experiment description of studies that identified kuz in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for kuz
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 sty  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which kuz is involved
No pathways found





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