Gene description for Src42A
Gene name Src oncogene at 42A
Gene symbol Src42A
Other names/aliases CG14471
CG44128
CG7873
DSrc42A
Dm SRC41
DmHD-29
DmelCG44128
Dmel_CG14471
Dmel_CG7873
Dsrc41
Dsrc42A
Dtk5
HD-29
SK2-4
SRC 42A
SRC42A
Src
Src41
Src42
Src42a
Su(D-raf)1
Su(Raf)1
Su(phl)1
Su1
Tk5
dSrc
dtk-5
dtk5
l(2)k10108
src
src42
src42A
src42a
Species Drosophila melanogaster
 Database cross references - Src42A
ExoCarta ExoCarta_35524
Vesiclepedia VP_35524
Entrez Gene 35524
UniProt Q9V9J3  
 Src42A identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Src42A
Molecular Function
    protein tyrosine kinase activity GO:0004713 NAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
Biological Process
    dorsal closure GO:0007391 IGI
    dorsal closure GO:0007391 IMP
    dorsal closure, spreading of leading edge cells GO:0007395 IMP
    axon guidance GO:0007411 IMP
    open tracheal system development GO:0007424 IMP
    salivary gland morphogenesis GO:0007435 IMP
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    cell migration GO:0016477 IMP
    adherens junction organization GO:0034332 IMP
    intestinal stem cell homeostasis GO:0036335 IMP
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IGI
    defense response to bacterium GO:0042742 IMP
    apoptotic cell clearance GO:0043277 IMP
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IMP
    positive regulation of sevenless signaling pathway GO:0045874 IDA
    negative regulation of synaptic assembly at neuromuscular junction GO:0045886 IGI
    imaginal disc fusion, thorax closure GO:0046529 IMP
    regulation of synaptic plasticity GO:0048167 IGI
    compound eye development GO:0048749 IMP
    actin filament bundle assembly GO:0051017 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    epithelial cell-cell adhesion GO:0090136 IMP
    positive regulation of inflammatory response to wounding GO:0106016 IGI
Subcellular Localization
    cytoplasm GO:0005737 HDA
    plasma membrane GO:0005886 HDA
 Experiment description of studies that identified Src42A in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Src42A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG43427  
Two-hybrid Drosophila melanogaster
2 Dok  
Two-hybrid Drosophila melanogaster
3 Pkn  
Two-hybrid Drosophila melanogaster
4 RpS27A  
Affinity Capture-Western Drosophila melanogaster
5 CG31342  
Two-hybrid Drosophila melanogaster
6 l(2)37Cg  
Two-hybrid Drosophila melanogaster
7 dx  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here