Gene description for Ggamma1
Gene name G protein gamma 1
Gene symbol Ggamma1
Other names/aliases CG8261
D-G[[gamma]]1
DmelCG8261
G[[gamma1]]
G[[gamma]]
Gbetagamma
Gg1
Ggamma
Ggamma-1
bro4
dg1alpha
l(2)k08017
Species Drosophila melanogaster
 Database cross references - Ggamma1
ExoCarta ExoCarta_35881
Vesiclepedia VP_35881
Entrez Gene 35881
UniProt P38040  
 Ggamma1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Ggamma1
Biological Process
    heart process GO:0003015 IMP
    establishment or maintenance of cytoskeleton polarity involved in gastrulation GO:0003380 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    dorsal closure GO:0007391 IMP
    proboscis extension reflex GO:0007637 IMP
    regulation of gastrulation GO:0010470 IMP
    embryonic heart tube development GO:0035050 IMP
    regulation of myosin II filament organization GO:0043519 IMP
    apical protein localization GO:0045176 TAS
    mesectoderm development GO:0048383 IMP
    asymmetric neuroblast division GO:0055059 IMP
    convergent extension involved in gastrulation GO:0060027 IMP
    cell adhesion involved in heart morphogenesis GO:0061343 IMP
Subcellular Localization
    heterotrimeric G-protein complex GO:0005834 IDA
 Experiment description of studies that identified Ggamma1 in exosomes
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ggamma1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG4407  
Affinity Capture-MS Drosophila melanogaster
2 Gbeta13F  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Ggamma1 is involved
PathwayEvidenceSource
Activation of G protein gated Potassium channels IEA Reactome
Activation of GABAB receptors IEA Reactome
Activation of kainate receptors upon glutamate binding IEA Reactome
ADP signalling through P2Y purinoceptor 12 IEA Reactome
Adrenaline,noradrenaline inhibits insulin secretion IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
Ca2+ pathway IEA Reactome
Chaperonin-mediated protein folding IEA Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding IEA Reactome
ESR-mediated signaling IEA Reactome
Extra-nuclear estrogen signaling IEA Reactome
G alpha (12/13) signalling events IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome
G alpha (s) signalling events IEA Reactome
G alpha (z) signalling events IEA Reactome
G beta:gamma signalling through BTK IEA Reactome
G beta:gamma signalling through CDC42 IEA Reactome
G beta:gamma signalling through PI3Kgamma IEA Reactome
G beta:gamma signalling through PLC beta IEA Reactome
G protein gated Potassium channels IEA Reactome
G-protein activation IEA Reactome
G-protein beta:gamma signalling IEA Reactome
GABA B receptor activation IEA Reactome
GABA receptor activation IEA Reactome
GPCR downstream signalling IEA Reactome
Hemostasis IEA Reactome
Inactivation, recovery and regulation of the phototransduction cascade IEA Reactome
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits IEA Reactome
Integration of energy metabolism IEA Reactome
Inwardly rectifying K+ channels IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Opioid Signalling IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
Platelet homeostasis IEA Reactome
Potassium Channels IEA Reactome
Presynaptic function of Kainate receptors IEA Reactome
Prostacyclin signalling through prostacyclin receptor IEA Reactome
Protein folding IEA Reactome
Regulation of insulin secretion IEA Reactome
Sensory Perception IEA Reactome
Signal amplification IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by WNT IEA Reactome
The phototransduction cascade IEA Reactome
Thromboxane signalling through TP receptor IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Visual phototransduction IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here