Gene description for Uba1
Gene name Ubiquitin activating enzyme 1
Gene symbol Uba1
Other names/aliases 2/31
CG1782
DmUba1
DmelCG1782
E1
FBtr0088499
UBA-1
Uba 1
l(2)03405
l(2)05642
l(2)s3484
uba-1
uba1
Species Drosophila melanogaster
 Database cross references - Uba1
ExoCarta ExoCarta_35998
Vesiclepedia VP_35998
Entrez Gene 35998
 Uba1 identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Uba1
Molecular Function
    ubiquitin activating enzyme activity GO:0004839 IDA
Biological Process
    protein polyubiquitination GO:0000209 IMP
    mitophagy GO:0000423 IMP
    macroautophagy GO:0016236 IMP
    mushroom body development GO:0016319 IMP
    neuron remodeling GO:0016322 IMP
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IMP
    lipid storage GO:0019915 IDA
    follicle cell of egg chamber development GO:0030707 IMP
    larval midgut cell programmed cell death GO:0035096 IMP
    regulation of growth GO:0040008 IMP
    glucose homeostasis GO:0042593 IMP
    regulation of programmed cell death GO:0043067 IGI
    regulation of programmed cell death GO:0043067 IMP
    regulation of Ras protein signal transduction GO:0046578 IMP
Subcellular Localization
    plasma membrane GO:0005886 HDA
    dendrite GO:0030425 IMP
 Experiment description of studies that identified Uba1 in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uba1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG2540  
Two-hybrid Drosophila melanogaster
2 grim  
Two-hybrid Drosophila melanogaster
3 Alas  
Two-hybrid Drosophila melanogaster
4 CTPsyn  
Proximity Label-MS Drosophila melanogaster
5 ci  
Two-hybrid Drosophila melanogaster
6 abs  
Two-hybrid Drosophila melanogaster
7 Pk17E  
Two-hybrid Drosophila melanogaster
8 rpr  
Two-hybrid Drosophila melanogaster
9 ben  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Uba1 is involved
No pathways found





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