Gene description for Slc47a1
Gene name solute carrier family 47 (multidrug and toxin extrusion), member 1
Gene symbol Slc47a1
Other names/aliases MATE1
RGD1311123
Species Rattus norvegicus
 Database cross references - Slc47a1
ExoCarta ExoCarta_360539
Vesiclepedia VP_360539
Entrez Gene 360539
UniProt Q5I0E9  
 Slc47a1 identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc47a1
Molecular Function
    organic cation transmembrane transporter activity GO:0015101 ISO
    organic cation transmembrane transporter activity GO:0015101 ISS
    L-amino acid transmembrane transporter activity GO:0015179 ISO
    thiamine transmembrane transporter activity GO:0015234 IEA
    thiamine transmembrane transporter activity GO:0015234 ISO
    thiamine transmembrane transporter activity GO:0015234 ISS
    antiporter activity GO:0015297 IEA
    antiporter activity GO:0015297 ISO
    putrescine transmembrane transporter activity GO:0015489 IEA
    putrescine transmembrane transporter activity GO:0015489 ISO
    putrescine transmembrane transporter activity GO:0015489 ISS
    amide transmembrane transporter activity GO:0042887 IDA
    xenobiotic transmembrane transporter activity GO:0042910 IBA
    xenobiotic transmembrane transporter activity GO:0042910 IDA
    xenobiotic transmembrane transporter activity GO:0042910 IEA
    xenobiotic transmembrane transporter activity GO:0042910 ISO
    L-arginine transmembrane transporter activity GO:0061459 IEA
    L-arginine transmembrane transporter activity GO:0061459 ISO
    polyspecific organic cation:proton antiporter activity GO:0140968 IDA
    polyspecific organic cation:proton antiporter activity GO:0140968 IEA
    polyspecific organic cation:proton antiporter activity GO:0140968 ISO
Biological Process
    monoatomic cation transport GO:0006812 IMP
    xenobiotic transmembrane transport GO:0006855 IEA
    xenobiotic transmembrane transport GO:0006855 ISO
    organic cation transport GO:0015695 IBA
    organic cation transport GO:0015695 IDA
    organic cation transport GO:0015695 ISO
    putrescine transport GO:0015847 IEA
    putrescine transport GO:0015847 ISO
    putrescine transport GO:0015847 ISS
    amide transport GO:0042886 IEA
    xenobiotic transport GO:0042908 ISO
    transmembrane transport GO:0055085 IDA
    thiamine transmembrane transport GO:0071934 IEA
    amino acid import across plasma membrane GO:0089718 ISO
    L-arginine import across plasma membrane GO:0097638 IEA
    L-arginine import across plasma membrane GO:0097638 ISO
    monoatomic cation transmembrane transport GO:0098655 IDA
    monoatomic cation transmembrane transport GO:0098655 ISO
    L-alpha-amino acid transmembrane transport GO:1902475 ISO
    proton transmembrane transport GO:1902600 IEA
    L-arginine transmembrane transport GO:1903826 IEA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IEA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IBA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    vesicle GO:0031982 IDA
 Experiment description of studies that identified Slc47a1 in sEVs
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc47a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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