Gene description for Tusc5
Gene name tumor suppressor candidate 5
Gene symbol Tusc5
Other names/aliases DSPB1
Species Rattus norvegicus
 Database cross references - Tusc5
ExoCarta ExoCarta_360576
Vesiclepedia VP_360576
Entrez Gene 360576
UniProt Q2MHH0  
 Tusc5 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tusc5
Biological Process
    cellular response to insulin stimulus GO:0032869 ISO
    cellular response to insulin stimulus GO:0032869 ISO
    cellular response to insulin stimulus GO:0032869 ISS
    glucose import in response to insulin stimulus GO:0044381 ISO
    glucose import in response to insulin stimulus GO:0044381 ISO
    glucose import in response to insulin stimulus GO:0044381 ISS
    establishment of localization in cell GO:0051649 ISO
    protein localization to plasma membrane GO:0072659 ISO
    protein localization to plasma membrane GO:0072659 ISO
    protein localization to plasma membrane GO:0072659 ISS
    vesicle fusion to plasma membrane GO:0099500 ISO
    endosome to plasma membrane protein transport GO:0099638 ISO
    endosome to plasma membrane protein transport GO:0099638 ISO
    endosome to plasma membrane protein transport GO:0099638 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    endomembrane system GO:0012505 IEA
    membrane GO:0016020 IBA
    cytoplasmic vesicle membrane GO:0030659 IDA
    cytoplasmic vesicle membrane GO:0030659 ISO
    cytoplasmic vesicle membrane GO:0030659 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Tusc5 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tusc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tusc5 is involved
No pathways found





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