ExoCarta: Gene summary

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Gene description for Lamtor4
Gene name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Gene symbol	Lamtor4
Other names/aliases	RGD1309735
Species	Rattus norvegicus
Database cross references - Lamtor4
ExoCarta	ExoCarta_360776
Entrez Gene	360776
Lamtor4 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Lamtor4

Molecular Function
	protein complex scaffold	GO:0032947	ISO
	guanyl-nucleotide exchange factor activity	GO:0005085	ISO
Biological Process
	positive regulation of TOR signaling	GO:0032008	ISO
	protein localization to lysosome	GO:0061462	ISO
	cellular response to amino acid stimulus	GO:0071230	ISO
	regulation of cell size	GO:0008361	ISO
	positive regulation of GTPase activity	GO:0043547	ISO
Subcellular Localization
	intracellular membrane-bounded organelle	GO:0043231	ISO
	lysosome	GO:0005764	ISO
	Ragulator complex	GO:0071986	ISO

Experiment description of studies that identified Lamtor4 in exosomes

Experiment ID

ISEV standards
✔ EM	EV Biophysical techniques
✔ TSG101\|HSP90\|HSC70	EV Cytosolic markers
✔ MHCI	EV Membrane markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D2 Rep 2

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting